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p(FPLX:AKT, pmod(Ph, Thr, 308))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
AKT
Namespace
FPLX
Namespace Version
20180917
Namespace URL
https://raw.githubusercontent.com/sorgerlab/famplex/e8ae9926ff95266032cb74f77973c84939bffbeb/export/famplex.belns

Appears in Networks 1

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer v1.0.0

In-Edges 2

p(FPLX:AKT) hasVariant p(FPLX:AKT, pmod(Ph, Thr, 308)) View Subject | View Object

Appears in Networks:

p(FPLX:PPP2) decreases p(FPLX:AKT, pmod(Ph, Thr, 308)) View Subject | View Object

Co-immunoprecipitation and in-vitro pull down assay using pro-lymphoid FL5.12 cells showed a direct association of the PP2A-B55 holoenzyme with Akt, which selectively regulates phosphorylation of Akt at Thr-308 and regulates cell proliferation and survival [58]. PubMed:23454242

Appears in Networks:

Out-Edges 1

p(FPLX:AKT, pmod(Ph, Thr, 308)) increases act(p(FPLX:AKT)) View Subject | View Object

Phosphorylation at Thr-308 and Ser-473 leads to activation of Akt and it was found that deregulation of Akt is associated with various human malignancies. PubMed:23454242

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.