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p(HBP:HBP00071)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
HBP00071
Namespace
HBP
Namespace Version
20181221
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/bd0996a28201cad363557315043c6392e31abf58/export/hbp.belns

Appears in Networks 2

APP processing in Alzheimer's disease v1.0.1

APP processing in Alzheimer's disease

Proteolytic processing of Alzeimer's beta-amyloid precursor protein v1.0.1

In-Edges 16

rxn(reactants(p(HBP:HBP00071)), products(a(HBP:HBP00069), a(HBP:HBP00070))) hasReactant p(HBP:HBP00071) View Subject | View Object

Appears in Networks:

complex(a(MESH:Clathrin), p(HBP:HBP00071)) hasComponent p(HBP:HBP00071) View Subject | View Object

Appears in Networks:

complex(p(HBP:HBP00071), p(HGNC:APBA1)) hasComponent p(HBP:HBP00071) View Subject | View Object

Appears in Networks:

complex(p(HBP:HBP00071), p(HGNC:APBB1)) hasComponent p(HBP:HBP00071) View Subject | View Object

Appears in Networks:

complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) hasComponent p(HBP:HBP00071) View Subject | View Object

Appears in Networks:

complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:TFCP2)) hasComponent p(HBP:HBP00071) View Subject | View Object

Appears in Networks:

complex(p(HBP:HBP00071), p(HGNC:DAB1)) hasComponent p(HBP:HBP00071) View Subject | View Object

Appears in Networks:

complex(p(HBP:HBP00071), p(HGNC:KLC1)) hasComponent p(HBP:HBP00071) View Subject | View Object

Appears in Networks:

complex(p(HBP:HBP00071), p(HGNC:MAPK8IP1)) hasComponent p(HBP:HBP00071) View Subject | View Object

Appears in Networks:

complex(p(HBP:HBP00071), p(HGNC:NAE1)) hasComponent p(HBP:HBP00071) View Subject | View Object

Appears in Networks:

complex(p(HBP:HBP00071), p(HGNC:NUMB)) hasComponent p(HBP:HBP00071) View Subject | View Object

Appears in Networks:

complex(p(HBP:HBP00071), p(HGNC:SHC1)) hasComponent p(HBP:HBP00071) View Subject | View Object

Appears in Networks:

complex(p(HBP:HBP00071), p(HGNC:SPAG9)) hasComponent p(HBP:HBP00071) View Subject | View Object

Appears in Networks:

p(HBP:HBP00071, pmod(Ph, Ser, 665)) association act(p(HBP:HBP00071)) View Subject | View Object

Such phosphorylation may affect APP processing or the binding of AICD-interacting proteins, thus affecting the function of AICD (Gandy et al. 1988; Suzuki et al. 1994; Iijima et al. 2000; Inomata et al. 2003) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

p(HBP:HBP00071, pmod(Ph, Thr, 654)) association act(p(HBP:HBP00071)) View Subject | View Object

Such phosphorylation may affect APP processing or the binding of AICD-interacting proteins, thus affecting the function of AICD (Gandy et al. 1988; Suzuki et al. 1994; Iijima et al. 2000; Inomata et al. 2003) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

p(HBP:HBP00071, pmod(Ph, Thr, 668)) association act(p(HBP:HBP00071)) View Subject | View Object

Such phosphorylation may affect APP processing or the binding of AICD-interacting proteins, thus affecting the function of AICD (Gandy et al. 1988; Suzuki et al. 1994; Iijima et al. 2000; Inomata et al. 2003) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

Out-Edges 10

p(HBP:HBP00071) hasVariant p(HBP:HBP00071, pmod(Ph, Ser, 665)) View Subject | View Object

Appears in Networks:

act(p(HBP:HBP00071)) association p(HBP:HBP00071, pmod(Ph, Ser, 665)) View Subject | View Object

Such phosphorylation may affect APP processing or the binding of AICD-interacting proteins, thus affecting the function of AICD (Gandy et al. 1988; Suzuki et al. 1994; Iijima et al. 2000; Inomata et al. 2003) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

p(HBP:HBP00071) hasVariant p(HBP:HBP00071, pmod(Ph, Thr, 654)) View Subject | View Object

Appears in Networks:

act(p(HBP:HBP00071)) association p(HBP:HBP00071, pmod(Ph, Thr, 654)) View Subject | View Object

Such phosphorylation may affect APP processing or the binding of AICD-interacting proteins, thus affecting the function of AICD (Gandy et al. 1988; Suzuki et al. 1994; Iijima et al. 2000; Inomata et al. 2003) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

p(HBP:HBP00071) hasVariant p(HBP:HBP00071, pmod(Ph, Thr, 668)) View Subject | View Object

Appears in Networks:

act(p(HBP:HBP00071)) association p(HBP:HBP00071, pmod(Ph, Thr, 668)) View Subject | View Object

Such phosphorylation may affect APP processing or the binding of AICD-interacting proteins, thus affecting the function of AICD (Gandy et al. 1988; Suzuki et al. 1994; Iijima et al. 2000; Inomata et al. 2003) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

p(HBP:HBP00071) increases bp(GO:"cell death") View Subject | View Object

Many studies have documented that AICD is cytotoxic and that over-expressing different AICDs (C31, C57, C59) in Hela, H4, N2a or PC12 cell lines, as well as neuronal cell lines, induces cell death (Lu et al. 2000) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

p(HBP:HBP00071) increases p(HGNC:TP53) View Subject | View Object

For example, P53 expression, as well as p53-mediated apoptosis, can be enhanced by AICD (Alves da Costa et al. 2006; Ozaki et al. 2006) PubMed:22122372

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons

p(HBP:HBP00071) increases act(p(HGNC:TP53)) View Subject | View Object

For example, P53 expression, as well as p53-mediated apoptosis, can be enhanced by AICD (Alves da Costa et al. 2006; Ozaki et al. 2006) PubMed:22122372

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons

p(HBP:HBP00071) regulates bp(GO:"calcium ion homeostasis") View Subject | View Object

In addition, cellular Ca2+ homeostasis appears to be modulated by AICD (Hamid et al. 2007) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.