path(MESH:Hemochromatosis)
Conversely, chronic transfusions associated with b-thalassemia major and sickle cell disease lead to hemochromatosis with end organ injury. PubMed:30281034
Accumulation of iron in tissue parenchyma with subsequent hemochromatosis is a well-known problem in chronic transfusion-dependent diseases such as b-thalassemia major, and in sickle cell disease patients when stroke prevention is indicated. PubMed:30281034
These studies do begin to suggest that apo-Tf administration could attenuate acute iron overload and hemochromatosis progression following chronic RBC transfusions. PubMed:30281034
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.