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r(HGNC:CHRNB4)

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Entity

Name
CHRNB4
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Naturally-expressed nicotinic acetylcholine receptor subtypes v1.0.0

In-Edges 4

act(complex(p(HGNC:JUN), p(HGNC:SP1)), ma(tscript)) increases r(HGNC:CHRNB4) View Subject | View Object

Subsequent studies have revealed that the DNA binding Sp-1 transcriptional factor interacts in response to NGF with the c-Jun coactivator (317) to increase beta4 transcription. PubMed:19126755

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Annotations
Text Location
Review

composite(p(HGNC:CHRNA7), p(HGNC:NGF)) increases r(HGNC:CHRNB4) View Subject | View Object

For example, in the original PC12 line (194), NGF is a potent inducer of beta4 transcription (217), but in PC12 lines that are defective in the expression of functional alpha7 nAChRs, NGF decreases beta4 nAChR subunit transcription (60, 397). PubMed:19126755

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MeSH
PC12 Cells
Text Location
Review

p(HGNCGENEFAMILY:"ETS transcription factor family") association r(HGNC:CHRNB4) View Subject | View Object

Several E26 transformation-specific sequence (ETS) factor binding sites were identified that upon deletion led to substantially diminished expression of both alpha3 and beta4, and to direct transgene expression of the reporter gene, LacZ, to major sites of gene cluster expression in multiple brain regions, ganglia, and peripheral systems. PubMed:19126755

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Text Location
Review

r(HGNC:CHRNA4) association r(HGNC:CHRNB4) View Subject | View Object

b4 subunit mRNA colocalizes with a4 subunit mRNA in many brain regions [37,38] that could be involved in complex behaviors including nicotine dependence. PubMed:21787755

Appears in Networks:
Annotations
MeSH
Brain

Out-Edges 2

r(HGNC:CHRNB4) association p(HGNCGENEFAMILY:"ETS transcription factor family") View Subject | View Object

Several E26 transformation-specific sequence (ETS) factor binding sites were identified that upon deletion led to substantially diminished expression of both alpha3 and beta4, and to direct transgene expression of the reporter gene, LacZ, to major sites of gene cluster expression in multiple brain regions, ganglia, and peripheral systems. PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

r(HGNC:CHRNB4) association r(HGNC:CHRNA4) View Subject | View Object

b4 subunit mRNA colocalizes with a4 subunit mRNA in many brain regions [37,38] that could be involved in complex behaviors including nicotine dependence. PubMed:21787755

Appears in Networks:
Annotations
MeSH
Brain

About

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.