a(PUBCHEM:23624255)
Ganetespib treatment had a strong effect on most Hsp90- client interactions. Of the 630 unique proteins that we detected by LUMIER assay, 46% significantly decreased their interaction with Hsp90beta (change in LUMIER score > 1.5, adjusted p value <0.05; Figure 4A) PubMed:25036637
Ganetespib treatment had a strong effect on most Hsp90- client interactions. Of the 630 unique proteins that we detected by LUMIER assay, 46% significantly decreased their interaction with Hsp90beta (change in LUMIER score > 1.5, adjusted p value <0.05; Figure 4A) PubMed:25036637
Ganetespib treatment had a strong effect on most Hsp90- client interactions. Of the 630 unique proteins that we detected by LUMIER assay, 46% significantly decreased their interaction with Hsp90beta (change in LUMIER score > 1.5, adjusted p value <0.05; Figure 4A) PubMed:25036637
A few, mostly cochaperones, decreased their interaction with both Hsp90b and Hsc70 (blue circles, Figure 4C). PubMed:25036637
Ganetespib treatment had a strong effect on most Hsp90- client interactions. Of the 630 unique proteins that we detected by LUMIER assay, 46% significantly decreased their interaction with Hsp90beta (change in LUMIER score > 1.5, adjusted p value <0.05; Figure 4A) PubMed:25036637
A few, mostly cochaperones, decreased their interaction with both Hsp90b and Hsc70 (blue circles, Figure 4C). PubMed:25036637
The effect of ganetespib on Hsc70 interactions was more subtle but still clearly detectable: 16% of the tested proteins increased their interaction with Hsc70 upon ganetespib treatment. This was particularly noticeable for proteins that interacted strongly with Hsc70 (Figure 4B). PubMed:25036637
The effect of ganetespib on Hsc70 interactions was more subtle but still clearly detectable: 16% of the tested proteins increased their interaction with Hsc70 upon ganetespib treatment. This was particularly noticeable for proteins that interacted strongly with Hsc70 (Figure 4B). PubMed:25036637
The effect of ganetespib on Hsc70 interactions was more subtle but still clearly detectable: 16% of the tested proteins increased their interaction with Hsc70 upon ganetespib treatment. This was particularly noticeable for proteins that interacted strongly with Hsc70 (Figure 4B). PubMed:25036637
The effect of ganetespib on Hsc70 interactions was more subtle but still clearly detectable: 16% of the tested proteins increased their interaction with Hsc70 upon ganetespib treatment. This was particularly noticeable for proteins that interacted strongly with Hsc70 (Figure 4B). PubMed:25036637
A few, mostly cochaperones, decreased their interaction with both Hsp90b and Hsc70 (blue circles, Figure 4C). PubMed:25036637
A few, mostly cochaperones, decreased their interaction with both Hsp90b and Hsc70 (blue circles, Figure 4C). PubMed:25036637
A few, mostly cochaperones, decreased their interaction with both Hsp90b and Hsc70 (blue circles, Figure 4C). PubMed:25036637
A few, mostly cochaperones, decreased their interaction with both Hsp90b and Hsc70 (blue circles, Figure 4C). PubMed:25036637
Interestingly, five proteins increased their interaction with both Hsp90 and Hsp70 after drug treatment (orange circles,Figure 4C) PubMed:25036637
Interestingly, five proteins increased their interaction with both Hsp90 and Hsp70 after drug treatment (orange circles,Figure 4C) PubMed:25036637
Interestingly, five proteins increased their interaction with both Hsp90 and Hsp70 after drug treatment (orange circles,Figure 4C) PubMed:25036637
Interestingly, five proteins increased their interaction with both Hsp90 and Hsp70 after drug treatment (orange circles,Figure 4C) PubMed:25036637
BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.
If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.