1. Catalog
  2. Nodes
  3. composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2))

composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2))

Appears in Networks 1

A role for b2* nicotinic receptors in a model of local amyloid pathology induced in dentate gyrus v1.0.0

In-Edges 0

Out-Edges 5

composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) hasComponent p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) View Subject | View Object

Appears in Networks:

composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) hasComponent p(MGI:Chrnb2) View Subject | View Object

Appears in Networks:

composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases path(MESH:"Memory Disorders") View Subject | View Object

In the NPR task (7 months p.i.), the GFP-beta2 spent significantly more time exploring the novel compartment (p = 0.003; Fig. 4A), as well as APP-beta2 (p = 0.017; Fig. 4B). PubMed:27522251

Appears in Networks:
Annotations
MeSH
Dentate Gyrus

composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases path(MESH:"Memory Disorders") View Subject | View Object

Similarly, in the NOR task (15 months p.i.), both the GFP-beta2 and the APP-beta2 displayed higher exploration of the novel object (p < 0.0001 and p = 0.0001, respectively; Fig. 4C and D), with no differences between the 2 groups in the recognition index (p = 0.7; Fig. 4E), meaning that beta2 mice injected with hAPP-SLA did not exhibit the recognition memory deficit observed in APP-WT PubMed:27522251

Appears in Networks:
Annotations
MeSH
Dentate Gyrus

composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases a(HBP:HBP00022) View Subject | View Object

We then investigated the presence of Abeta aggregates in the hippocampus of APP-beta2 and APP-alpha7. In APP-beta2, a positive staining for Abeta oligomers using the VHH 31-1 antibody was found (Fig. 8, arrows) PubMed:27522251

Appears in Networks:
Annotations
MeSH
Hippocampus

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.