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p(HGNC:MAPT, var("p.Leu256Glu"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
MAPT
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau v1.0.0

In-Edges 1

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, var("p.Leu256Glu")) View Subject | View Object

Appears in Networks:

Out-Edges 2

p(HGNC:MAPT, var("p.Leu256Glu")) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) View Subject | View Object

When compared to the wild-type peptide, Tau(254–290)-L266E showed a decreased STD signal (Supplementary Figure 10c–e), indicating that the mutation attenuated F-actin binding PubMed:29215007

Appears in Networks:
Annotations
Confidence
High

p(HGNC:MAPT, var("p.Leu256Glu")) decreases bp(GO:"actin filament bundle assembly") View Subject | View Object

In agreement with a decrease in affinity of Tau(254–290)-L266E for binding to F-actin (Supplementary Fig. 1), the mutant peptide was less efficient in promoting F-actin bundling (Supplementary Fig. 10f) PubMed:29215007

Appears in Networks:
Annotations
Confidence
High

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.