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complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290")))

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Components

Appears in Networks 1

Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau v1.0.0

In-Edges 2

p(HGNC:MAPT, frag("254_290")) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) View Subject | View Object

When compared to the wild-type peptide, Tau(254–290)-L266E showed a decreased STD signal (Supplementary Figure 10c–e), indicating that the mutation attenuated F-actin binding PubMed:29215007

Appears in Networks:
Annotations
Confidence
High

p(HGNC:MAPT, var("p.Leu256Glu")) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) View Subject | View Object

When compared to the wild-type peptide, Tau(254–290)-L266E showed a decreased STD signal (Supplementary Figure 10c–e), indicating that the mutation attenuated F-actin binding PubMed:29215007

Appears in Networks:
Annotations
Confidence
High

Out-Edges 3

complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) hasComponent p(HGNC:MAPT, frag("254_290")) View Subject | View Object

Appears in Networks:

complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) hasComponent a(GO:"filamentous actin") View Subject | View Object

Appears in Networks:

complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) increases bp(MESH:"Protein Conformation, alpha-Helical") View Subject | View Object

Sequential resonance assignment of the peptide (Supplementary Table 3), followed by NOE analysis (Supplementary Fig. 13) and structure calculations (Supplementary Fig. 14) showed that the short peptide folds into an α-helix (residues 259–265) in complex with F-actin that is similar to the one found in Tau(254–290) (Supplementary Fig. 14b) PubMed:29215007

Appears in Networks:
Annotations
Confidence
High

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.