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Appears in Networks 5

In-Edges 3

a(CHEBI:Salidroside) regulates p(HGNC:NFKBIA) View Subject | View Object

Salidroside ameliorated cognitive injury in an AD rat model by regulating the expressions of thioredoxin, thioredoxin interacting protein and NF-B pathway proteins such as NF-B p65, IB, IKK and IKK[137]. PubMed:29179999

a(CHEBI:curcumin) decreases deg(p(HGNC:NFKBIA)) View Subject | View Object

Inhibition of the NF-B pathway represents a well-defined anti-inflammatory mechanism of curcumin[104,105]. Curcumin inhibited the phosphorylation and degrada-tion of IB and the nuclear translocation of NF-B p65 [106]. PubMed:29179999

a(PUBCHEM:73078) decreases deg(p(HGNC:NFKBIA)) View Subject | View Object

It inhibited the degradation of IkBa, a cytoplasmic NF-B inhibitor, and p65translocation to the nucleus by disabling IkBa alpha kinase beta and  activiies [181,182]. PubMed:29179999

Out-Edges 6

p(HGNC:NFKBIA) decreases a(CHEBI:"amyloid-beta") View Subject | View Object

IkBa expression plasmid was also transfected into SAS1 cells and IkBa transfection reduced Ab protein levels to 92.24¡2.68% (p<0.05). PubMed:21329555

p(HGNC:NFKBIA) decreases act(p(FPLX:NFkappaB)) View Subject | View Object

It inhibited the degradation of IkBa, a cytoplasmic NF-B inhibitor, and p65translocation to the nucleus by disabling IkBa alpha kinase beta and  activiies [181,182]. PubMed:29179999

p(HGNC:NFKBIA) decreases act(p(FPLX:NFkappaB)) View Subject | View Object

ROS generation leads to phosphorylation of NF-κB cytoplasmic inhibitor IκBα. NF-κB is thus liberated and transports to the nucleus. PubMed:27288790

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.