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p(FPLX:NFkappaB, pmod(Ph, Ser, 536))

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Entity

Name
NFkappaB
Namespace
FPLX
Namespace Version
20190217
Namespace URL
https://raw.githubusercontent.com/sorgerlab/famplex/d9ec0526c20795146a9a6aef17496efe1a36cac6/export/famplex.belns

Appears in Networks 2

Chronic Anatabine Treatment Reduces Alzheimer ’ s Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD v1.0.0

Upstream regulators and downstream effectors of NF-κBinAlzheimer's disease v1.0.0

In-Edges 3

p(FPLX:NFkappaB) hasVariant p(FPLX:NFkappaB, pmod(Ph, Ser, 536)) View Subject | View Object

Appears in Networks:

a(CHEBI:Anatabine) decreases p(FPLX:NFkappaB, pmod(Ph, Ser, 536)) View Subject | View Object

Interestingly, we found a significant reduction in the expression of amyloid plaque associated phospho-p65 NFκB immunopositive cells in Tg PS1/APPswe mice treated with anatabine at either 10 or 20 mg/Kg/Day (Fig 7B) showing that anatabine prevents NFκB activation in the brain of Tg PS1/APPswe mice. PubMed:26010758

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease

a(CHEBI:"amyloid-beta polypeptide 42") increases p(FPLX:NFkappaB, pmod(Ph, Ser, 536)) View Subject | View Object

Results have shown a sig- nificant increase in phosphorylation of IκB at serine 32–36 and NF-κB at serine 536 with Aβ 42 exposure, this phosphorylation enhances p65 transactivation potential [16]. PubMed:27288790

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Out-Edges 1

p(FPLX:NFkappaB, pmod(Ph, Ser, 536)) increases act(p(HGNC:RELA)) View Subject | View Object

Results have shown a sig- nificant increase in phosphorylation of IκB at serine 32–36 and NF-κB at serine 536 with Aβ 42 exposure, this phosphorylation enhances p65 transactivation potential [16]. PubMed:27288790

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.