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complex(GO:"filamentous actin")

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Entity

Name
filamentous actin
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 4

Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau v1.0.0

Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers v1.0.0

TAU and Interaction Partners v1.2.5

TAU Interactions Section of NESTOR

Tau in physiology and pathology v1.0.0

In-Edges 7

composite(complex(GO:"filamentous actin"), p(HGNC:CFL1)) hasComponent complex(GO:"filamentous actin") View Subject | View Object

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composite(complex(GO:"filamentous actin"), p(HGNC:CFL1)) decreases complex(GO:"filamentous actin") View Subject | View Object

One of these binding partners is cofilin, a 21 kDa eukaryotic protein, which binds to F-actin with a Kd < 0.05 μM33 and results in disassembly of F-actin34, 35. Cryo-electron microscopy further showed that the binding site of cofilin on F-actin is highly similar to its binding site on G-actin (Fig. 2a)32 PubMed:29215007

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Annotations
Confidence
Medium

bp(GO:"actin filament polymerization") increases complex(GO:"filamentous actin") View Subject | View Object

We analyzed actin and tau in the PSD-enriched fraction from primary cortical neurons treated with jasplakinolide (Fig. 5E). We observed that increased neuronal F-actin content promotes concurrent tau enrichment (*p0.0150, 2-tailed Student’s t test; control 17.49  0.7755 vs jasplakinolide 27.02  2719, N  4 independent cultures; Fig. 5F). GLUA1, the membrane trafficking of which is known to be actin dependent, was increased (*p 0.0279, 2-tailed Student’s t test; control 16.91  1015 vs jasplakinolide 31.00  4.778, N  4 independent cultures). The amount of Fyn in the PSD was decreased (*p  0.0265, 2-tailed Student’s t test; control 27.25 5.003 vs jasplakinolide 11.71  1.786, N  4 independent cultures). PubMed:24760868

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Annotations
MeSH
Post-Synaptic Density
Text Location
Results

p(HGNC:MAPT) association complex(GO:"filamentous actin") View Subject | View Object

These results show that the amount of tau collected is proportional to neuronal F-actin content, suggesting a close link between F-actin and tau. PubMed:24760868

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Annotations
MeSH
Neurons
Text Location
Results

complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) hasComponent complex(GO:"filamentous actin") View Subject | View Object

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p(HGNC:MAPT) directlyIncreases complex(GO:"filamentous actin") View Subject | View Object

These results are consistent with previous in vitro studies and indicate that tau induces actin-filament bundling in vitro and F-actin accumulation in vivo, most likely through a direct interaction with F-actin.For genetic analysis, we selected a line of tauV337M-expressing flies that has a moderate rough eye and is a good substrate for genetic modification. Coexpressing an actin transgene (UAS–Act5C–EGFP;GMR– GAL4 driver) markedly enhanced tauV337M-induced toxicity. PubMed:17187063

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p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases complex(GO:"filamentous actin") View Subject | View Object

In a Drosophila melanogaster model of tauopathy, the hyperphosphorylation of tau led to the abnormal alignment and accumulation of F‑actin filaments, and thereby induced neurodegeneration PubMed:26631930

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Out-Edges 4

complex(GO:"filamentous actin") association p(HGNC:MAPT) View Subject | View Object

These results show that the amount of tau collected is proportional to neuronal F-actin content, suggesting a close link between F-actin and tau. PubMed:24760868

Appears in Networks:
Annotations
MeSH
Neurons
Text Location
Results

complex(GO:"filamentous actin") increases p(HGNC:MAPT) View Subject | View Object

We analyzed actin and tau in the PSD-enriched fraction from primary cortical neurons treated with jasplakinolide (Fig. 5E). We observed that increased neuronal F-actin content promotes concurrent tau enrichment (*p0.0150, 2-tailed Student’s t test; control 17.49  0.7755 vs jasplakinolide 27.02  2719, N  4 independent cultures; Fig. 5F). GLUA1, the membrane trafficking of which is known to be actin dependent, was increased (*p 0.0279, 2-tailed Student’s t test; control 16.91  1015 vs jasplakinolide 31.00  4.778, N  4 independent cultures). The amount of Fyn in the PSD was decreased (*p  0.0265, 2-tailed Student’s t test; control 27.25 5.003 vs jasplakinolide 11.71  1.786, N  4 independent cultures). PubMed:24760868

Appears in Networks:
Annotations
MeSH
Post-Synaptic Density
Text Location
Results

complex(GO:"filamentous actin") increases p(HGNC:MAPT, loc(GO:synapse)) View Subject | View Object

Together, these results suggest that tau translocation to the synapse depends on the F-actin stabilization that promotes their interaction. PubMed:24760868

Appears in Networks:
Annotations
Text Location
Results

complex(GO:"filamentous actin") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) View Subject | View Object

These results are consistent with previous in vitro studies and indicate that tau induces actin-filament bundling in vitro and F-actin accumulation in vivo, most likely through a direct interaction with F-actin.For genetic analysis, we selected a line of tauV337M-expressing flies that has a moderate rough eye and is a good substrate for genetic modification. Coexpressing an actin transgene (UAS–Act5C–EGFP;GMR– GAL4 driver) markedly enhanced tauV337M-induced toxicity. PubMed:17187063

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.