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rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067)))

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Appears in Networks 2

APP processing in Alzheimer's disease v1.0.1

APP processing in Alzheimer's disease

Proteolytic processing of Alzeimer's beta-amyloid precursor protein v1.0.1

In-Edges 7

p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) View Subject | View Object

From the TGN, APP can be transported in TGN-derived secretory vesicles to the cell surface where it is either cleaved by alpha-secretase to produce a soluble molecule, sAPPalpha [37], or re-internalized via an endosomal/ lysosomal degradation pathway [38,39] PubMed:21214928

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) View Subject | View Object

Cleavage of APP by alpha-secretase precludes Abeta generation as the cleavage site is within the Abeta domain (at the Lys16- Leu17 bond), and releases a large soluble ectodomain of APP called sAPPalpha PubMed:21214928

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons

p(HGNC:ADAM17) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) View Subject | View Object

Manipulation of ADAM17 can alter alpha-cleavage of APP and Abeta generation, with regulated alpha-cleavage abolished in ADAM17-deficient cells, suggesting that ADAM17 is likely the alpha-secretase responsible for regulated APP cleavage [47] PubMed:21214928

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons

p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) View Subject | View Object

APP can also be cleaved by alpha-secretase to form a soluble or secreted APP ectodomain (sAPP-alpha) that has been shown to be mostly neuro-protective PubMed:22122372

Appears in Networks:
Annotations
Confidence
High

p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) View Subject | View Object

As APP was found to be constitutively cleaved at the alpha-site to yield sAPP-alpha (Esch et al. 1990), three members of the a disintegrin and metalloproteinase (ADAMs), ADAM-10,ADAM-17 and ADAM-9 have been proposed as the alpha-secretase (Buxbaum et al. 1998; Koike et al. 1999;Lammich et al. 1999) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

p(HGNC:ADAM17) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) View Subject | View Object

As APP was found to be constitutively cleaved at the alpha-site to yield sAPP-alpha (Esch et al. 1990), three members of the a disintegrin and metalloproteinase (ADAMs), ADAM-10,ADAM-17 and ADAM-9 have been proposed as the alpha-secretase (Buxbaum et al. 1998; Koike et al. 1999;Lammich et al. 1999) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

p(HGNC:ADAM9) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) View Subject | View Object

As APP was found to be constitutively cleaved at the alpha-site to yield sAPP-alpha (Esch et al. 1990), three members of the a disintegrin and metalloproteinase (ADAMs), ADAM-10,ADAM-17 and ADAM-9 have been proposed as the alpha-secretase (Buxbaum et al. 1998; Koike et al. 1999;Lammich et al. 1999) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

Out-Edges 2

rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) hasReactant p(HGNC:APP) View Subject | View Object

Appears in Networks:

rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) hasProduct a(HBP:HBP00067) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.