p(HGNC:ADAM17) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067)))

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PubMed:22122372

As APP was found to be constitutively cleaved at the alpha-site to yield sAPP-alpha (Esch et al. 1990), three members of the a disintegrin and metalloproteinase (ADAMs), ADAM-10,ADAM-17 and ADAM-9 have been proposed as the alpha-secretase (Buxbaum et al. 1998; Koike et al. 1999;Lammich et al. 1999)

Related Edges 2

• p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067)))
• p(HGNC:ADAM9) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067)))

Confidence

High

MeSH

Neurons

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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