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complex(a(MESH:Actins), p(HGNC:MAPT))

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Components

Appears in Networks 1

Tau in physiology and pathology v1.0.0

In-Edges 2

p(HGNC:MAPT) directlyIncreases complex(a(MESH:Actins), p(HGNC:MAPT)) View Subject | View Object

In addition, tau may interact with actin to induce aligned bundles of actin filaments, thus modifying the organization of the cytoskeleton network PubMed:26631930

Appears in Networks:

p(HGNC:MAPT, pmod(Ph)) decreases complex(a(MESH:Actins), p(HGNC:MAPT)) View Subject | View Object

The phosphorylation of tau appears to alter its association with actin, as tau phosphorylated at the KXGS motifs tends to colocalize with actin filaments in growth cones during development and in rod-like inclusions of cofilin and actin PubMed:26631930

Appears in Networks:

Out-Edges 4

complex(a(MESH:Actins), p(HGNC:MAPT)) hasComponent a(MESH:Actins) View Subject | View Object

Appears in Networks:

complex(a(MESH:Actins), p(HGNC:MAPT)) hasComponent p(HGNC:MAPT) View Subject | View Object

Appears in Networks:

complex(a(MESH:Actins), p(HGNC:MAPT)) increases a(GO:"actin filament bundle") View Subject | View Object

In addition, tau may interact with actin to induce aligned bundles of actin filaments, thus modifying the organization of the cytoskeleton network PubMed:26631930

Appears in Networks:

complex(a(MESH:Actins), p(HGNC:MAPT)) regulates a(GO:"actin cytoskeleton") View Subject | View Object

In addition, tau may interact with actin to induce aligned bundles of actin filaments, thus modifying the organization of the cytoskeleton network PubMed:26631930

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.