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complex(a(GO:microtubule), a(MESH:Kinesin))

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Components

Appears in Networks 3

Alpha-synuclein oligomers: a new hope v1.0.0

Tau oligomers and tau toxicity in neurodegenerative disease v1.0.0

Tau oligomers and tau toxicity in neurodegenerative disease by Ward et al., 2012

Tau in physiology and pathology v1.0.0

In-Edges 3

a(HBP:HBP00093) decreases complex(a(GO:microtubule), a(MESH:Kinesin)) View Subject | View Object

The trafficking of synaptic vesicles may also be negatively impacted by a-syn oligomers, which have been shown to decrease axonal transport by decreasing microtubule stability and impairing the interaction between kinesin and microtubules [128], as well as inhibiting tubulin polymerisation [20]. PubMed:28803412

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Microglia

p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Kinesin)) View Subject | View Object

Tau reportedly exerts an effect on axonal transport by interfering and reducing the attachment frequency of the motor proteins to the microtubules [28] PubMed:22817713

Appears in Networks:
Annotations
Confidence
High
MeSH
Intracellular Space

p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Kinesin)) View Subject | View Object

First, tau competes with kinesin or dynein motors for binding to microtubules, reducing the binding frequency, motile fraction and run length of kinesin and dynein (without changing the motor velocity of kinesin and dynein), and thereby slowing down both anterograde and retrograde transport PubMed:26631930

Appears in Networks:

Out-Edges 2

complex(a(GO:microtubule), a(MESH:Kinesin)) hasComponent a(GO:microtubule) View Subject | View Object

Appears in Networks:

complex(a(GO:microtubule), a(MESH:Kinesin)) hasComponent a(MESH:Kinesin) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.