p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Kinesin))

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PubMed:26631930

First, tau competes with kinesin or dynein motors for binding to microtubules, reducing the binding frequency, motile fraction and run length of kinesin and dynein (without changing the motor velocity of kinesin and dynein), and thereby slowing down both anterograde and retrograde transport

Related Edges 3

• p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Dyneins))
• p(HGNC:MAPT) decreases bp(GO:"anterograde axonal transport")
• p(HGNC:MAPT) decreases bp(GO:"retrograde axonal transport")

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