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p(MGI:Rela, pmod(Ph))

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Entity

Name
Rela
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

Amelioration of Experimental Autoimmune Encephalomyelitis by Anatabine v1.0.0

In-Edges 5

a(CHEBI:Anatabine) decreases p(MGI:Rela, pmod(Ph)) View Subject | View Object

We have shown previously that anatabine prevents STAT3 and p65 NFkB phosphorylation in various cell types and suggested that anatabine impact cytokine production by this mechanism as both STAT3 and p65 NFkB are known to regulate cytokine production. PubMed:23383175

Appears in Networks:

a(CHEBI:Anatabine) decreases p(MGI:Rela, pmod(Ph)) View Subject | View Object

Additionally, we observed that anatabine significantly prevented STAT3 and p65 NFkB phosphorylation in brain homogenates of EAE mice (Fig. 4) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Encephalomyelitis

p(MGI:Rela) hasVariant p(MGI:Rela, pmod(Ph)) View Subject | View Object

Appears in Networks:

p(MGI:Stat3, pmod(Ph)) positiveCorrelation p(MGI:Rela, pmod(Ph)) View Subject | View Object

In addition, we observed a statistically significant correlation between the amount of p65 NFkB phosphorylation and STAT3 phosphorylation in brain homogenates (Pearson Correlation = 0.637, P<0.001) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:Encephalomyelitis) increases p(MGI:Rela, pmod(Ph)) View Subject | View Object

Western-blot experiments using brain homogenates from EAE mice also reveal that both STAT3 and p65 NFkB phosphorylation are significantly elevated in the brain of EAE mice compared to control non immunized mice (Fig. 4) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Brain

Out-Edges 1

p(MGI:Rela, pmod(Ph)) positiveCorrelation p(MGI:Stat3, pmod(Ph)) View Subject | View Object

In addition, we observed a statistically significant correlation between the amount of p65 NFkB phosphorylation and STAT3 phosphorylation in brain homogenates (Pearson Correlation = 0.637, P<0.001) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Brain

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.