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r(HGNC:CHRNA3)

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Entity

Name
CHRNA3
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Nicotinic Receptor Abnormalities of Alzheimer’s Disease: Therapeutic Implications v1.0.0

In-Edges 7

a(MESH:Adult) decreases r(HGNC:CHRNA3) View Subject | View Object

For instance, the alpha3 nAChR transcript generally dominates in the prenatal brain or in injured neurons, whereas its expression tends to be downregulated in the adult or healthy neuron, and alpha4 transcription is increased. PubMed:19126755

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a(MESH:Fetus) increases r(HGNC:CHRNA3, loc(MESH:Brain)) View Subject | View Object

For instance, the alpha3 nAChR transcript generally dominates in the prenatal brain or in injured neurons, whereas its expression tends to be downregulated in the adult or healthy neuron, and alpha4 transcription is increased. PubMed:19126755

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Text Location
Review

a(MESH:Neurons) decreases r(HGNC:CHRNA3) View Subject | View Object

For instance, the alpha3 nAChR transcript generally dominates in the prenatal brain or in injured neurons, whereas its expression tends to be downregulated in the adult or healthy neuron, and alpha4 transcription is increased. PubMed:19126755

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Text Location
Review

p(HGNCGENEFAMILY:"ETS transcription factor family") association r(HGNC:CHRNA3) View Subject | View Object

Several E26 transformation-specific sequence (ETS) factor binding sites were identified that upon deletion led to substantially diminished expression of both alpha3 and beta4, and to direct transgene expression of the reporter gene, LacZ, to major sites of gene cluster expression in multiple brain regions, ganglia, and peripheral systems. PubMed:19126755

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path(MESH:"Trauma, Nervous System") increases r(HGNC:CHRNA3, loc(MESH:Brain)) View Subject | View Object

For instance, the alpha3 nAChR transcript generally dominates in the prenatal brain or in injured neurons, whereas its expression tends to be downregulated in the adult or healthy neuron, and alpha4 transcription is increased. PubMed:19126755

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Text Location
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bp(GO:aging) causesNoChange r(HGNC:CHRNA3) View Subject | View Object

The levels of alpha4 and alpha7 nAChR mRNA showed a decrease with aging, whereas the levels of alpha3 mRNA were unchanged in the elderly brain relative to the fetal brain (Hellstro¨m-Lindahl et al 1998) PubMed:11230871

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MeSH
Brain

path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:CHRNA3) View Subject | View Object

Examination of the regional expression of mRNA of the nAChR alpha4 and alpha3 subunits has shown no difference in autopsy AD brain tissue in any region analyzed (Hellstro ¨m-Lindahl et al 1999; Terzano et al 1998), whereas the level of the alpha7 mRNA was significantly higher in the hippocampus (Hellstro¨m-Lindahl et al 1999) PubMed:11230871

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MeSH
Hippocampus

Out-Edges 1

r(HGNC:CHRNA3) association p(HGNCGENEFAMILY:"ETS transcription factor family") View Subject | View Object

Several E26 transformation-specific sequence (ETS) factor binding sites were identified that upon deletion led to substantially diminished expression of both alpha3 and beta4, and to direct transgene expression of the reporter gene, LacZ, to major sites of gene cluster expression in multiple brain regions, ganglia, and peripheral systems. PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.