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a(MESH:"Nitric Oxide Synthase")

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Entity

Name
Nitric Oxide Synthase
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 4

a(CHEBI:enflurane) decreases a(MESH:"Nitric Oxide Synthase") View Subject | View Object

In vitro, direct exposure of vascular strips,38,39 brain tissue,40 polymorphoneutrophils, 41 and thoracic aorta42 to volatile anesthetic agents such as enflurane, isoflurane, and halothane has been shown to reversibly inhibit NOS activity. PubMed:27308950

Appears in Networks:
Annotations
MeSH
Plasma
Text Location
Discussion

a(CHEBI:halothane) decreases a(MESH:"Nitric Oxide Synthase") View Subject | View Object

In vitro, direct exposure of vascular strips,38,39 brain tissue,40 polymorphoneutrophils, 41 and thoracic aorta42 to volatile anesthetic agents such as enflurane, isoflurane, and halothane has been shown to reversibly inhibit NOS activity. PubMed:27308950

Appears in Networks:
Annotations
MeSH
Plasma
Text Location
Discussion

a(CHEBI:isoflurane) decreases a(MESH:"Nitric Oxide Synthase") View Subject | View Object

In vitro, direct exposure of vascular strips,38,39 brain tissue,40 polymorphoneutrophils, 41 and thoracic aorta42 to volatile anesthetic agents such as enflurane, isoflurane, and halothane has been shown to reversibly inhibit NOS activity. PubMed:27308950

Appears in Networks:
Annotations
MeSH
Plasma
Text Location
Discussion

path(MESH:Hyperlipidemias) decreases act(a(MESH:"Nitric Oxide Synthase")) View Subject | View Object

Mice with diabetes mellitus or hyperlipidemia have evidence of endothelial dysfunction, which is associated with reduced nitric oxide synthase (NOS) 3 activity (15, 16). PubMed:28314763

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Annotations
Text Location
Introduction

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.