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p(HGNC:PTPA)

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Entity

Name
PTPA
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 3

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer v1.0.0

Assembly and structure of protein phosphatase 2A v1.0.0

Protein phosphatase 2A dysfunction in Alzheimer’s disease v1.0.0

In-Edges 4

p(FPLX:"PPP2R_B") hasComponent p(HGNC:PTPA) View Subject | View Object

Appears in Networks:

complex(p(HGNC:PPP2CA), p(HGNC:PTPA)) hasComponent p(HGNC:PTPA) View Subject | View Object

Appears in Networks:

complex(p(HGNC:PPP2CB), p(HGNC:PTPA)) hasComponent p(HGNC:PTPA) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PTPA) View Subject | View Object

Decreased expression levels of PTPA in AD brain tissue may also lead to inactivation of PP2A by indirectly increasing levels of PP2A phosphorylated at the Tyr-307 site (Luo et al.,2013). PubMed:24653673

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Out-Edges 6

p(HGNC:PTPA) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) View Subject | View Object

Deletion of PTPA homologs in yeast, rrd1/rrd2, resulted in elevated levels of stable PP2A-PME-1 complexes, accompanied by decreased methylation PubMed:19277525

Appears in Networks:

p(HGNC:PTPA) increases act(complex(GO:"protein phosphatase type 2A complex")) View Subject | View Object

A portion of cellular PP2A stably associated with PME-1 and was catalytically inactive [80]; intriguingly, this inactive portion of PP2A could be re-activated by PP2A phosphatase activator (PTPA), but not by LCMT1, ruling out the possibility that inactivation was solely caused by demethylation PubMed:19277525

Appears in Networks:

p(HGNC:PTPA) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) View Subject | View Object

Deletion of PTPA homologs in yeast, rrd1/rrd2, resulted in elevated levels of stable PP2A-PME-1 complexes, accompanied by decreased methylation PubMed:19277525

Appears in Networks:

p(HGNC:PTPA) negativeCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Decreased expression levels of PTPA in AD brain tissue may also lead to inactivation of PP2A by indirectly increasing levels of PP2A phosphorylated at the Tyr-307 site (Luo et al.,2013). PubMed:24653673

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:PTPA) increases act(complex(GO:"protein phosphatase type 2A complex")) View Subject | View Object

Decreased expression levels of PTPA in AD brain tissue may also lead to inactivation of PP2A by indirectly increasing levels of PP2A phosphorylated at the Tyr-307 site (Luo et al.,2013). PubMed:24653673

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:PTPA) decreases p(FPLX:PPP2, pmod(Ph, Tyr, 307)) View Subject | View Object

Decreased expression levels of PTPA in AD brain tissue may also lead to inactivation of PP2A by indirectly increasing levels of PP2A phosphorylated at the Tyr-307 site (Luo et al.,2013). PubMed:24653673

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.