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p(MGI:Cdc42)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Cdc42
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 5

a(CHEBI:heme) increases act(p(MGI:Cdc42)) View Subject | View Object

Heme stimulation of RAW264.7 macrophages induced immediate Cdc42 activation for up to 30 min after stimulation (Fig. 6d), without inducing changes in total Cdc42 protein amounts (Supplementary Fig. 6b). PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

a(MESH:Pseudopodia) positiveCorrelation p(MGI:Cdc42) View Subject | View Object

Cdc42 is involved in cell motility and phagocytosis, but is mainly recognized as being a central node in the formation of lamellipodia and filopodia at the leading edge3 PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

bp(MESH:"Cell Movement") positiveCorrelation p(MGI:Cdc42) View Subject | View Object

Cdc42 is involved in cell motility and phagocytosis, but is mainly recognized as being a central node in the formation of lamellipodia and filopodia at the leading edge3 PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

bp(MESH:Phagocytosis) positiveCorrelation p(MGI:Cdc42) View Subject | View Object

Cdc42 is involved in cell motility and phagocytosis, but is mainly recognized as being a central node in the formation of lamellipodia and filopodia at the leading edge3 PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

p(MGI:Dock8) positiveCorrelation p(MGI:Cdc42) View Subject | View Object

In contrast with wild-type ER-HoxB8 BMDMs, Dock8−/− ER-HoxB8 BMDM did not spread or extend filopodia (Fig. 7a,b), and failed to activate Cdc42 following treatment with heme (Fig. 7c), indicating that DOCK8 was essential for heme-induced activation of Cdc42. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

Out-Edges 4

p(MGI:Cdc42) positiveCorrelation bp(MESH:"Cell Movement") View Subject | View Object

Cdc42 is involved in cell motility and phagocytosis, but is mainly recognized as being a central node in the formation of lamellipodia and filopodia at the leading edge3 PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

p(MGI:Cdc42) positiveCorrelation bp(MESH:Phagocytosis) View Subject | View Object

Cdc42 is involved in cell motility and phagocytosis, but is mainly recognized as being a central node in the formation of lamellipodia and filopodia at the leading edge3 PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

p(MGI:Cdc42) positiveCorrelation a(MESH:Pseudopodia) View Subject | View Object

Cdc42 is involved in cell motility and phagocytosis, but is mainly recognized as being a central node in the formation of lamellipodia and filopodia at the leading edge3 PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

p(MGI:Cdc42) positiveCorrelation p(MGI:Dock8) View Subject | View Object

In contrast with wild-type ER-HoxB8 BMDMs, Dock8−/− ER-HoxB8 BMDM did not spread or extend filopodia (Fig. 7a,b), and failed to activate Cdc42 following treatment with heme (Fig. 7c), indicating that DOCK8 was essential for heme-induced activation of Cdc42. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.