bp(GO:"cellular protein catabolic process")

Entity

Name

cellular protein catabolic process

Namespace

go

Namespace Version

20190207

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/a5b84013a08880975ca84f40999e4404b14a97e2/external/go-names.belns

CHIP binds Hsp90 and Hsp70 with similar affinities and can regulate the degradation of chaperone clients (Kundrat and Regan, 2010). PubMed:25036637

These three proteins localize to cytoplasmic structures known as processing bodies, or P bodies, which are involved in mRNA decapping, degradation, and translational silencing (Eulalio et al., 2007) PubMed:25036637

These three proteins localize to cytoplasmic structures known as processing bodies, or P bodies, which are involved in mRNA decapping, degradation, and translational silencing (Eulalio et al., 2007) PubMed:25036637

These three proteins localize to cytoplasmic structures known as processing bodies, or P bodies, which are involved in mRNA decapping, degradation, and translational silencing (Eulalio et al., 2007) PubMed:25036637

Surprisingly, the axonal grains of Tau appear to resist protein degradation because they are negative for markers of degradation (vimentin, ubiquitin, Lamp1, Sqstm1/P62, Hsc70, and Tia-1) (Fig. S5) PubMed:27671637

Intracellular protein degradation is performed by UPS and ALS (Wong and Cuervo 2010 PubMed:29626319

Intracellular protein degradation is performed by UPS and ALS (Wong and Cuervo 2010 PubMed:29626319

UPS-mediated catabolism is also essential to mainten amino acid pools in acute starvation and contributes significantly to the degradation of defective proteins [1,2,7]. PubMed:18930136

Autophagy, by contrast, is primarily responsible for degrading long-lived proteins and maintaining amino acid pools in the setting of chronic starvation, although its contribution to the degradation of defective proteins may equal that of the UPS. PubMed:18930136

Considering the importance of protein catabolism in maintaining cell homeostasis, it is not surprising that dysregulation of protein turnover is associated with myriad disease states such as cancer and neurodegeneration [5]. PubMed:18930136

Considering the importance of protein catabolism in maintaining cell homeostasis, it is not surprising that dysregulation of protein turnover is associated with myriad disease states such as cancer and neurodegeneration [5]. PubMed:18930136

AGEs induce tau hyperphosphorylation, memory deterioration, decline of synaptic proteins, and impairment of long-term potentiation in rats [10]. PubMed:27288790

These three proteins localize to cytoplasmic structures known as processing bodies, or P bodies, which are involved in mRNA decapping, degradation, and translational silencing (Eulalio et al., 2007) PubMed:25036637

These three proteins localize to cytoplasmic structures known as processing bodies, or P bodies, which are involved in mRNA decapping, degradation, and translational silencing (Eulalio et al., 2007) PubMed:25036637

These three proteins localize to cytoplasmic structures known as processing bodies, or P bodies, which are involved in mRNA decapping, degradation, and translational silencing (Eulalio et al., 2007) PubMed:25036637

Surprisingly, the axonal grains of Tau appear to resist protein degradation because they are negative for markers of degradation (vimentin, ubiquitin, Lamp1, Sqstm1/P62, Hsc70, and Tia-1) (Fig. S5) PubMed:27671637

Considering the importance of protein catabolism in maintaining cell homeostasis, it is not surprising that dysregulation of protein turnover is associated with myriad disease states such as cancer and neurodegeneration [5]. PubMed:18930136

Considering the importance of protein catabolism in maintaining cell homeostasis, it is not surprising that dysregulation of protein turnover is associated with myriad disease states such as cancer and neurodegeneration [5]. PubMed:18930136

Considering the importance of protein catabolism in maintaining cell homeostasis, it is not surprising that dysregulation of protein turnover is associated with myriad disease states such as cancer and neurodegeneration [5]. PubMed:18930136