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bp(GO:"lysosomal microautophagy")

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Entity

Name
lysosomal microautophagy
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 4

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing v1.0.0

Clearance of Amyloid Beta and Tau in Alzheimer’s Disease:from Mechanisms to Therapy v1.0.1

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection v1.0.0

In-Edges 3

a(CHEBI:selenomethionine) increases bp(GO:"lysosomal microautophagy") View Subject | View Object

Selenium deficits have been linked to AD, and thus it is interesting that seleno- methionine boosted ALN flux, from AMPK recruit- ment through autophagosome formation to lysosomal degradation, in the 3×Tg AD mouse model 112 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons

complex(GO:"TOR complex") increases bp(GO:"lysosomal microautophagy") View Subject | View Object

And autophagy-lysosomal activity is induced via two signal pathways: mammalian target of rapamycin (mTOR)-dependent pathway and mTORindependent pathway (Tan et al. 2014b) PubMed:29626319

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path(MESH:"Alzheimer Disease") decreases bp(GO:"lysosomal microautophagy") View Subject | View Object

However, their dysfunction in AD due to some factors will reduce Aβ clearance PubMed:29626319

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Out-Edges 9

bp(GO:"lysosomal microautophagy") increases bp(GO:"cellular protein catabolic process") View Subject | View Object

Intracellular protein degradation is performed by UPS and ALS (Wong and Cuervo 2010 PubMed:29626319

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bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:"amyloid-beta")) View Subject | View Object

Intracellular Aβ clearance can be achieved through UPS and ALS, and extracellular Aβ is degraded by glial phagocytosis, such as microglia, astrocytes, and proteases from neurons and astrocytes (Fig. 2) PubMed:29626319

Appears in Networks:
Annotations
MeSH
Intracellular Space

bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:"amyloid-beta")) View Subject | View Object

Intracellular Aβ degradation pathways mainly contain two major pathways: UPS and ALS (Vilchez et al. 2014) PubMed:29626319

Appears in Networks:
Annotations
MeSH
Intracellular Space

bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:"amyloid-beta")) View Subject | View Object

In addition, there is accumulating evidence to prove that Aβ can be cleared by ALS. PubMed:29626319

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bp(GO:"lysosomal microautophagy") decreases a(HBP:"Tau aggregates") View Subject | View Object

On the one hand, it is beneficial to the clearance of tau aggregates PubMed:29626319

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bp(GO:"lysosomal microautophagy") increases p(HGNC:MAPT, frag("?")) View Subject | View Object

On the other hand, it brings about tau fragmentation into pro-aggregating forms due to the failure of F1 to enter the lysosome PubMed:29626319

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bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:lysosome)) View Subject | View Object

Microautophagy involves the nonselective entry of small quantities of cytoplasm into lysosomes or late endosomes/MVBs when the limiting membranes of these compartments invaginate and pinch off small vesicles for digestion within the lumen (Sahu et al. 2011). PubMed:22908190

Appears in Networks:

bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:"multivesicular body")) View Subject | View Object

Microautophagy involves the nonselective entry of small quantities of cytoplasm into lysosomes or late endosomes/MVBs when the limiting membranes of these compartments invaginate and pinch off small vesicles for digestion within the lumen (Sahu et al. 2011). PubMed:22908190

Appears in Networks:

bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:lysosome)) View Subject | View Object

Microautophagy consists of direct engulfment of small volumes of cytosol by lysosomes [10], whereas chaperone-mediated autophagy (CMA) involves selective, receptor-mediated translocation of proteins into the lysosomal lumen [11]. PubMed:18930136

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.