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p(MGI:Chrna5)

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Entity

Name
Chrna5
Namespace
MGI
Namespace Version
20170725
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/namespace/mgi-mouse-genes/mgi-mouse-genes-20170725.belns

Appears in Networks 1

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors. v1.0.0

In-Edges 0

Out-Edges 2

p(MGI:Chrna5) regulates act(a(MESH:Nicotine)) View Subject | View Object

α5 subunit Ko mice or mice with selective knock down of the α5 subunits in the Hb develop increased nicotine intake in a self-administration paradigm that is blocked by the selective re-expression of the α5 subunit within the MHb; thus indicating that the α5-containing nAChRs located in this brain area also play an important role in regulating the negative effects of nicotine. PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

p(MGI:Chrna5) increases a(MESH:Nicotine) View Subject | View Object

Finally, a study has shown that α2 Ko mice have enhanced nicotine self-administration behaviour [88]. These findings suggest that α5* nAChRs in the MHb, and α2* nAChRs in the IPN may underlie aversive responses to nicotine. PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.