p(MGI:Chrna5) regulates act(a(MESH:Nicotine))

PubMed:28901280

α5 subunit Ko mice or mice with selective knock down of the α5 subunits in the Hb develop increased nicotine intake in a self-administration paradigm that is blocked by the selective re-expression of the α5 subunit within the MHb; thus indicating that the α5-containing nAChRs located in this brain area also play an important role in regulating the negative effects of nicotine.

MeSH

GABAergic Neurons

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