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a(GO:"glutamatergic synapse")

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Entity

Name
glutamatergic synapse
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 3

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1

Tau in physiology and pathology v1.0.0

The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapse v1.0.0

In-Edges 4

act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases a(GO:"glutamatergic synapse") View Subject | View Object

Moreover, it was demonstrated that the activation of alpha7 nAChRs is important during development for the maturation of glutamatergic synapses (Lozada et al., 2012) PubMed:25514383

Appears in Networks:

complex(p(HGNC:DLG4), p(HGNC:FYN)) increases act(a(GO:"glutamatergic synapse")) View Subject | View Object

In addition, dendritic tau could serve as a protein scaffold to deliver the kinase FYN to postsynaptic sites, where FYN phosphorylates subunit 2 of the NMDA receptor (NR2B; also known as GluN2B), resulting in the stabilization of the interaction of this receptor interaction with postsynaptic density protein 95 (PSD95; also known as DLG4), potentiating glutamatergic signalling and thereby enhancing Aβ toxicity. PubMed:26631930

Appears in Networks:
Annotations
MeSH
Dendritic Spines

act(a(PUBCHEM:9832404)) association a(GO:"glutamatergic synapse") View Subject | View Object

Our original cell culture results showed NAP protection against excitotoxicity over a broad concentration range, suggesting an involvement of the glutamatergic system in ADNP/NAP activity PubMed:30664622

Appears in Networks:

act(p(HGNC:ADNP)) association a(GO:"glutamatergic synapse") View Subject | View Object

Our original cell culture results showed NAP protection against excitotoxicity over a broad concentration range, suggesting an involvement of the glutamatergic system in ADNP/NAP activity PubMed:30664622

Appears in Networks:

Out-Edges 2

a(GO:"glutamatergic synapse") association act(a(PUBCHEM:9832404)) View Subject | View Object

Our original cell culture results showed NAP protection against excitotoxicity over a broad concentration range, suggesting an involvement of the glutamatergic system in ADNP/NAP activity PubMed:30664622

Appears in Networks:

a(GO:"glutamatergic synapse") association act(p(HGNC:ADNP)) View Subject | View Object

Our original cell culture results showed NAP protection against excitotoxicity over a broad concentration range, suggesting an involvement of the glutamatergic system in ADNP/NAP activity PubMed:30664622

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.