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  4. Dendritic Spines

Dendritic Spines

Name
Dendritic Spines
Namespace Keyword
MeSHAnatomy
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-anatomy/mesh-anatomy-20170511.belanno

Sample Annotated Edges 5

p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(GO:postsynapse) View Subject | View Object

PSD-95, a marker of postsynaptic spines, decreased up to 50% in the TauRDΔK oligomer-treated cells, compared with buffer- and monomer-treated cells PubMed:28528849

Appears in Networks:
Annotations
MeSH
Dendritic Spines

p(HGNC:MAPT) increases complex(p(HGNC:DLG4), p(HGNC:FYN)) View Subject | View Object

In addition, dendritic tau could serve as a protein scaffold to deliver the kinase FYN to postsynaptic sites, where FYN phosphorylates subunit 2 of the NMDA receptor (NR2B; also known as GluN2B), resulting in the stabilization of the interaction of this receptor interaction with postsynaptic density protein 95 (PSD95; also known as DLG4), potentiating glutamatergic signalling and thereby enhancing Aβ toxicity. PubMed:26631930

Appears in Networks:
Annotations
MeSH
Dendritic Spines

complex(p(HGNC:DLG4), p(HGNC:FYN)) increases act(a(CHEBI:"amyloid-beta")) View Subject | View Object

In addition, dendritic tau could serve as a protein scaffold to deliver the kinase FYN to postsynaptic sites, where FYN phosphorylates subunit 2 of the NMDA receptor (NR2B; also known as GluN2B), resulting in the stabilization of the interaction of this receptor interaction with postsynaptic density protein 95 (PSD95; also known as DLG4), potentiating glutamatergic signalling and thereby enhancing Aβ toxicity. PubMed:26631930

Appears in Networks:
Annotations
MeSH
Dendritic Spines

p(HGNC:FYN) increases p(HGNC:GRIN2B, pmod(Ph)) View Subject | View Object

In addition, dendritic tau could serve as a protein scaffold to deliver the kinase FYN to postsynaptic sites, where FYN phosphorylates subunit 2 of the NMDA receptor (NR2B; also known as GluN2B), resulting in the stabilization of the interaction of this receptor interaction with postsynaptic density protein 95 (PSD95; also known as DLG4), potentiating glutamatergic signalling and thereby enhancing Aβ toxicity. PubMed:26631930

Appears in Networks:
Annotations
MeSH
Dendritic Spines

p(HGNC:MAPT) increases act(a(CHEBI:"amyloid-beta")) View Subject | View Object

In addition, dendritic tau could serve as a protein scaffold to deliver the kinase FYN to postsynaptic sites, where FYN phosphorylates subunit 2 of the NMDA receptor (NR2B; also known as GluN2B), resulting in the stabilization of the interaction of this receptor interaction with postsynaptic density protein 95 (PSD95; also known as DLG4), potentiating glutamatergic signalling and thereby enhancing Aβ toxicity. PubMed:26631930

Appears in Networks:
Annotations
MeSH
Dendritic Spines

Showing 5 of 12 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.