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p(HGNC:KLC1)

Equivalencies: 0 | Classes: 1 | Children: 0 | Explore

Entity

Name
KLC1
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 3

Proteolytic processing of Alzeimer's beta-amyloid precursor protein v1.0.1

TAU and Interaction Partners v1.2.5

TAU Interactions Section of NESTOR

Axonal Transport, Tau Protein, and Neurodegeneration in Alzheimer’s Disease v1.0.0

In-Edges 4

complex(p(HBP:HBP00071), p(HGNC:KLC1)) hasComponent p(HGNC:KLC1) View Subject | View Object

Appears in Networks:

act(complex(GO:"kinesin complex")) positiveCorrelation act(p(HGNC:KLC1)) View Subject | View Object

These include the scaffold protein JNK interacting protein (JIP) that is involved in the linkage of cargos to the kinesin-I motor complex via KLC (25, 28–33).This complex is formed by the kinesin heavy chain (KIF5; previously termed KHC), which interacts with microtubules, and kinesin light chain (KLC), which mediates cargo linkage. In addition, scaffolding proteins are involved such as the JIP1 that binds to KLC (21). PubMed:19491104

Appears in Networks:

p(HGNC:MAPK8IP1) association p(HGNC:KLC1) View Subject | View Object

These include the scaffold protein JNK interacting protein (JIP) that is involved in the linkage of cargos to the kinesin-I motor complex via KLC (25, 28–33).This complex is formed by the kinesin heavy chain (KIF5; previously termed KHC), which interacts with microtubules, and kinesin light chain (KLC), which mediates cargo linkage. In addition, scaffolding proteins are involved such as the JIP1 that binds to KLC (21). PubMed:19491104

Appears in Networks:

complex(p(HGNC:APP), p(HGNC:KLC1)) hasComponent p(HGNC:KLC1) View Subject | View Object

Appears in Networks:

Out-Edges 4

act(p(HGNC:KLC1)) positiveCorrelation act(complex(GO:"kinesin complex")) View Subject | View Object

These include the scaffold protein JNK interacting protein (JIP) that is involved in the linkage of cargos to the kinesin-I motor complex via KLC (25, 28–33).This complex is formed by the kinesin heavy chain (KIF5; previously termed KHC), which interacts with microtubules, and kinesin light chain (KLC), which mediates cargo linkage. In addition, scaffolding proteins are involved such as the JIP1 that binds to KLC (21). PubMed:19491104

Appears in Networks:

p(HGNC:KLC1) isA complex(GO:"kinesin complex") View Subject | View Object

Appears in Networks:

p(HGNC:KLC1) association p(HGNC:MAPK8IP1) View Subject | View Object

These include the scaffold protein JNK interacting protein (JIP) that is involved in the linkage of cargos to the kinesin-I motor complex via KLC (25, 28–33).This complex is formed by the kinesin heavy chain (KIF5; previously termed KHC), which interacts with microtubules, and kinesin light chain (KLC), which mediates cargo linkage. In addition, scaffolding proteins are involved such as the JIP1 that binds to KLC (21). PubMed:19491104

Appears in Networks:

p(HGNC:KLC1) increases bp(GO:"anterograde axonal transport") View Subject | View Object

Most recently, this role became even more puz- zling, since APP was implemented as a kinesin-1 receptor (Kamal et al., 2000; 2001). APP apparently binds to the light chain of kinesin-1, which itself is responsible for anterograde axonal transport and consists of two light chains (KLC) associated with two heavy chains (KIF5B). PubMed:12428809

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.