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p(MESH:Ubiquitin)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Ubiquitin
Namespace
mesh
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/mesh-names.belns

Appears in Networks 1

Clearance systems in the brain-implications for Alzheimer disease. v1.0.1

In-Edges 0

Out-Edges 3

act(p(MESH:Ubiquitin)) decreases p(HGNC:APP) View Subject | View Object

Intracellular degradation of proteins occurs via the ubiquitin– proteasome pathway, the autophagy–lysosome pathway, and the endosome–lysosome pathway.56 PubMed:26195256

Appears in Networks:

act(p(MESH:Ubiquitin)) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) View Subject | View Object

Intracellular Aβ (iAβ) can be degraded by proteasomes via the ubiquitin–proteasome pathway in neurons,116 lyso- somal cathepsin enzymes,117 proteases (such as insulin- degrading enzyme, a thiol metalloendopeptidase that degrades monomeric Aβ) and insulin. PubMed:26195256

Appears in Networks:

p(MESH:Ubiquitin) decreases p(HGNC:MAPT) View Subject | View Object

Tau is mainly cleared through intracellular degrada- tion by lysosomes via the autophagy–lysosome pathway, and by proteasomes via the ubiquitin–proteasome pathway.202 PubMed:26195256

Appears in Networks:
Annotations
MeSH
Choroid Plexus

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.