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  3. complex(a(MESH:DNA), p(FPLX:NFkappaB))

complex(a(MESH:DNA), p(FPLX:NFkappaB))

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Components

Appears in Networks 2

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease v1.0.0

Upstream regulators and downstream effectors of NF-κBinAlzheimer's disease v1.0.0

In-Edges 3

a(CHEBI:genistein) decreases complex(a(MESH:DNA), p(FPLX:NFkappaB)) View Subject | View Object

Pretreatment with genistein significantly alleviated A 25-35-stimulated TLR4 and NF-B expres-sion, DNA binding and NF-B activities[159]. PubMed:29179999

Appears in Networks:

a(PUBCHEM:44584733) decreases complex(a(MESH:DNA), p(FPLX:NFkappaB)) View Subject | View Object

Punicalagin decreased the expression of COX2 and DNA binding of NF-B in human colon cancer cell line [126]. PubMed:29179999

Appears in Networks:

act(p(FPLX:NFkappaB)) increases complex(a(MESH:DNA), p(FPLX:NFkappaB)) View Subject | View Object

Under different envi- ronmental conditions such as Aβ/ROS/cytokines accumulation, the IκB kinase (IKK) complex becomes activated and mediates the phosphoryla- tion of IκBs, then IκBs are degradated and the remaining NF-κB dimer is activated and thus translocates to the nucleus where it binds to the DNA consensus sequence of various target genes [9–11]. PubMed:27288790

Appears in Networks:
Annotations
MeSH
Cell Nucleus

Out-Edges 2

complex(a(MESH:DNA), p(FPLX:NFkappaB)) hasComponent a(MESH:DNA) View Subject | View Object

Appears in Networks:

complex(a(MESH:DNA), p(FPLX:NFkappaB)) hasComponent p(FPLX:NFkappaB) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.