p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")

Entity

Name

Protein phosphatase 2A, regulatory B subunit, B56

Namespace

interpro

Namespace Version

20181021

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/interpro-names.belns

The B′ regulatory subunit shows remarkable structural mimicry to the scaffold subunit and contains 8 HEAT-like repeats PubMed:19277525

To gain full activity towards specific substrates, the PP2A core enzyme interacts with a variable regulatory subunit to form a heterotrimeric holoenzyme. The variable regulatory subunits consist of four families: B (also known as B55 or PR55), B′ (B56 or PR61), B′′ (PR48/PR72/PR130), and B′′′ (PR93/PR110), with at least 16 members in these families PubMed:19277525

Except the B′′′ subunits, direct interactions between the PP2A core enzyme and the regulatory subunits have been demonstrated PubMed:19277525

The B′ regulatory subunit shows remarkable structural mimicry to the scaffold subunit and contains 8 HEAT-like repeats PubMed:19277525

For example, two regions of the B′ subunit were found to mediate interaction with the scaffold subunit of PP2A PubMed:19277525

Furthermore, the B′ subunit makes significant interactions with the catalytic subunit of PP2A, which consequently strengthens the inter-subunit packing, making the resulting holoenzyme relatively compact and rigid (Figure 2B). PubMed:19277525

For instance, some B’ subunits target PP2A to the nucleus (McCright et al., 1996) or the centrosome (Flegg et al.,2010); Bα subunits can direct some PP2A pools to microtubules, which could serve as a cytoskeletal reservoir of inac- tive enzymes (Sontag et al.,1995; Hiraga and Tamura,2000). PubMed:24653673

For instance, some B’ subunits target PP2A to the nucleus (McCright et al., 1996) or the centrosome (Flegg et al.,2010); Bα subunits can direct some PP2A pools to microtubules, which could serve as a cytoskeletal reservoir of inac- tive enzymes (Sontag et al.,1995; Hiraga and Tamura,2000). PubMed:24653673