apoptosome

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name: apoptosome
Namespace: go
Namespace Version: 20180921
Namespace URL: https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 1

Activation and regulation of the inflammasomes v1.0.0

In-Edges 1

tloc(p(HGNC:CYCS), fromLoc(MESH:Mitochondria), toLoc(MESH:Cytosol)) increases act(complex(GO:apoptosome)) View Subject | View Object

Indeed, inflammasomes (which induce pyroptosis through caspase 1 or caspase 11 activation) and apoptosomes (which activate caspase 9 in response to cytochrome c release from mitochondria) are two mechanisms by which compromised cells are eliminated. PubMed:23702978

Appears in Networks:

Activation and regulation of the inflammasomes v1.0.0

Annotations

Confidence: Medium
NeuroMMSigDB: Apoptosis signaling subgraph
NeuroMMSigDB: Caspase subgraph
NeuroMMSigDB: XIAP subgraph

Out-Edges 1

act(complex(GO:apoptosome)) increases act(p(HGNC:CASP9)) View Subject | View Object

Appears in Networks:

Activation and regulation of the inflammasomes v1.0.0

Annotations

Confidence: Medium
NeuroMMSigDB: Apoptosis signaling subgraph
NeuroMMSigDB: Caspase subgraph
NeuroMMSigDB: XIAP subgraph

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.