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p(HGNC:DISC1)

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Entity

Name
DISC1
Namespace
hgnc
Namespace Version
20190224
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/efc856fb009a39e4d284269a6801f79ed3d3cf56/external/hgnc-names.belns

Appears in Networks 1

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders v1.0.0

In-Edges 12

a(GO:dendrite) association p(HGNC:DISC1) View Subject | View Object

This gene encodes for the DISC1 ubiquitous protein, which is implicated in neurogenesis, neuronal migration, axon/dendrite, and synapse formation PubMed:30061532

Appears in Networks:

a(GO:synapse) association p(HGNC:DISC1) View Subject | View Object

This gene encodes for the DISC1 ubiquitous protein, which is implicated in neurogenesis, neuronal migration, axon/dendrite, and synapse formation PubMed:30061532

Appears in Networks:

complex(a(GO:"actin cytoskeleton"), p(HGNC:DISC1)) hasComponent p(HGNC:DISC1) View Subject | View Object

Appears in Networks:

bp(GO:"axon development") association p(HGNC:DISC1) View Subject | View Object

This gene encodes for the DISC1 ubiquitous protein, which is implicated in neurogenesis, neuronal migration, axon/dendrite, and synapse formation PubMed:30061532

Appears in Networks:

bp(GO:"dopamine secretion, neurotransmission") association p(HGNC:DISC1) View Subject | View Object

Remarkably, DISC1 plays a key role in DA neurotransmission PubMed:30061532

Appears in Networks:

bp(GO:"neuron migration") association p(HGNC:DISC1) View Subject | View Object

This gene encodes for the DISC1 ubiquitous protein, which is implicated in neurogenesis, neuronal migration, axon/dendrite, and synapse formation PubMed:30061532

Appears in Networks:

bp(MESH:Neurogenesis) association p(HGNC:DISC1) View Subject | View Object

This gene encodes for the DISC1 ubiquitous protein, which is implicated in neurogenesis, neuronal migration, axon/dendrite, and synapse formation PubMed:30061532

Appears in Networks:

complex(a(GO:microtubule), p(HGNC:DISC1)) hasComponent p(HGNC:DISC1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CCDC88A), p(HGNC:DISC1)) hasComponent p(HGNC:DISC1) View Subject | View Object

Appears in Networks:

p(HGNC:NRG1) regulates p(HGNC:DISC1) View Subject | View Object

Moreover, it has been demonstrated that NRG1 also regulates DISC1 expression [230], thus further worsening the aberrancy of the Akt–mTOR pathway and the pathogenesis of schizophrenia and related behaviors. PubMed:30061532

Appears in Networks:

path(MESH:Schizophrenia) association p(HGNC:DISC1) View Subject | View Object

Preliminary in vitro studies demonstrated that two proteins, namely DISC1 and dysbindin-1, which are encoded by two susceptibility genes for schizophrenia, can form insoluble protein aggregates that are reminiscent of those occurring in neurodegenerative disorders PubMed:30061532

Appears in Networks:

path(MESH:Schizophrenia) association p(HGNC:DISC1) View Subject | View Object

Intriguingly, the interactome analysis of both DISC1, dysbindin-1, and CRMP2, which is another susceptibility gene for schizophrenia, revealed common protein interactions with microtubules, actin cytoskeleton, and proteins involved in intracellular transport PubMed:30061532

Appears in Networks:

Out-Edges 11

p(HGNC:DISC1) hasVariant p(HGNC:DISC1, var("?")) View Subject | View Object

Appears in Networks:

p(HGNC:DISC1) association path(MESH:Schizophrenia) View Subject | View Object

Preliminary in vitro studies demonstrated that two proteins, namely DISC1 and dysbindin-1, which are encoded by two susceptibility genes for schizophrenia, can form insoluble protein aggregates that are reminiscent of those occurring in neurodegenerative disorders PubMed:30061532

Appears in Networks:

p(HGNC:DISC1) association path(MESH:Schizophrenia) View Subject | View Object

Intriguingly, the interactome analysis of both DISC1, dysbindin-1, and CRMP2, which is another susceptibility gene for schizophrenia, revealed common protein interactions with microtubules, actin cytoskeleton, and proteins involved in intracellular transport PubMed:30061532

Appears in Networks:

p(HGNC:DISC1) increases a(HBP:"protein aggregates") View Subject | View Object

Preliminary in vitro studies demonstrated that two proteins, namely DISC1 and dysbindin-1, which are encoded by two susceptibility genes for schizophrenia, can form insoluble protein aggregates that are reminiscent of those occurring in neurodegenerative disorders PubMed:30061532

Appears in Networks:

p(HGNC:DISC1) association bp(MESH:Neurogenesis) View Subject | View Object

This gene encodes for the DISC1 ubiquitous protein, which is implicated in neurogenesis, neuronal migration, axon/dendrite, and synapse formation PubMed:30061532

Appears in Networks:

p(HGNC:DISC1) association bp(GO:"neuron migration") View Subject | View Object

This gene encodes for the DISC1 ubiquitous protein, which is implicated in neurogenesis, neuronal migration, axon/dendrite, and synapse formation PubMed:30061532

Appears in Networks:

p(HGNC:DISC1) association bp(GO:"axon development") View Subject | View Object

This gene encodes for the DISC1 ubiquitous protein, which is implicated in neurogenesis, neuronal migration, axon/dendrite, and synapse formation PubMed:30061532

Appears in Networks:

p(HGNC:DISC1) association a(GO:dendrite) View Subject | View Object

This gene encodes for the DISC1 ubiquitous protein, which is implicated in neurogenesis, neuronal migration, axon/dendrite, and synapse formation PubMed:30061532

Appears in Networks:

p(HGNC:DISC1) association a(GO:synapse) View Subject | View Object

This gene encodes for the DISC1 ubiquitous protein, which is implicated in neurogenesis, neuronal migration, axon/dendrite, and synapse formation PubMed:30061532

Appears in Networks:

p(HGNC:DISC1) association bp(GO:"dopamine secretion, neurotransmission") View Subject | View Object

Remarkably, DISC1 plays a key role in DA neurotransmission PubMed:30061532

Appears in Networks:

p(HGNC:DISC1) decreases act(p(HGNC:CCDC88A)) View Subject | View Object

In particular, DISC1 acts by blocking KIAA1212, an Akt-binding partner, which directly interacts with Akt and strengthens the activation of this kinase, which represents a major mediator of the mTOR pathway. PubMed:30061532

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.