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p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")

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Entity

Name
Protein phosphatase 2A regulatory subunit PR55
Namespace
interpro
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/interpro-names.belns

Appears in Networks 2

Assembly and structure of protein phosphatase 2A v1.0.0

Protein phosphatase 2A dysfunction in Alzheimer’s disease v1.0.0

In-Edges 9

complex(p(HGNC:PPP2CA), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) hasComponent p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") View Subject | View Object

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complex(p(HGNC:MAPT), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) hasComponent p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") View Subject | View Object

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complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) hasComponent p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") View Subject | View Object

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complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) hasComponent p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") View Subject | View Object

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p(INTERPRO:"WD40 repeat") association p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") View Subject | View Object

In fact, the B subunit is now known to contain multiple WD40 repeats [28], whereas B′′/PR72 is thought to contain two calcium-binding EF hands PubMed:19277525

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complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) hasComponent p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") View Subject | View Object

Appears in Networks:

complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) hasComponent p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") View Subject | View Object

Appears in Networks:

complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) hasComponent p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") View Subject | View Object

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path(MESH:"Alzheimer Disease") negativeCorrelation p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") View Subject | View Object

More specifically, decreased expression levels of PP2A regulatory Bγ (or PPP2R2C) and B’ε (or PPP2R5E) subunit mRNAs in the hippocampus (Vogelsberg-Ragaglia et al.,2001), and cortical Bα subunit (Sontag et al.,2004b) have been reported in AD. PubMed:24653673

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Annotations
MeSH
Cerebral Cortex

Out-Edges 12

p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) View Subject | View Object

To gain full activity towards specific substrates, the PP2A core enzyme interacts with a variable regulatory subunit to form a heterotrimeric holoenzyme. The variable regulatory subunits consist of four families: B (also known as B55 or PR55), B′ (B56 or PR61), B′′ (PR48/PR72/PR130), and B′′′ (PR93/PR110), with at least 16 members in these families PubMed:19277525

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p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) View Subject | View Object

Except the B′′′ subunits, direct interactions between the PP2A core enzyme and the regulatory subunits have been demonstrated PubMed:19277525

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p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) View Subject | View Object

Structure of the heterotrimeric PP2A holoenzyme involving a regulatory B subunit (Figure 2D) reveals how B subunit specifically recognizes the PP2A core enzyme and how it may facilitate substrate dephosphorylation PubMed:19277525

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p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") association p(INTERPRO:"WD40 repeat") View Subject | View Object

In fact, the B subunit is now known to contain multiple WD40 repeats [28], whereas B′′/PR72 is thought to contain two calcium-binding EF hands PubMed:19277525

Appears in Networks:

p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases bp(GO:"protein dephosphorylation") View Subject | View Object

Structure of the heterotrimeric PP2A holoenzyme involving a regulatory B subunit (Figure 2D) reveals how B subunit specifically recognizes the PP2A core enzyme and how it may facilitate substrate dephosphorylation PubMed:19277525

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p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) View Subject | View Object

Unlike the PP2A holoenzyme involving the B′ subunit, B makes few interactions with the catalytic subunit PubMed:19277525

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p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) View Subject | View Object

This analysis further suggests that the B subunit may form a relatively stable complex with the isolated scaffold subunit and does not seem to support the notion that the catalytic subunit is required for interaction between the scaffold and the B subunits PubMed:19277525

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p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) View Subject | View Object

Previous investigations indicate that specific dephosphorylation of Tau appeared to be mediated by the B family of regulatory subunits PubMed:19277525

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p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases act(complex(GO:"protein phosphatase type 2A complex")) View Subject | View Object

For instance, the Bα subunit specifically and markedly facilitates dephosphory- lation of tau by PP2A (Sontag et al.,1996; Xu et al.,2008). PubMed:24653673

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p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") decreases p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

For instance, the Bα subunit specifically and markedly facilitates dephosphory- lation of tau by PP2A (Sontag et al.,1996; Xu et al.,2008). PubMed:24653673

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p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(a(GO:"protein phosphatase type 2A complex"), a(GO:microtubule)) View Subject | View Object

For instance, some B’ subunits target PP2A to the nucleus (McCright et al., 1996) or the centrosome (Flegg et al.,2010); Bα subunits can direct some PP2A pools to microtubules, which could serve as a cytoskeletal reservoir of inac- tive enzymes (Sontag et al.,1995; Hiraga and Tamura,2000). PubMed:24653673

Appears in Networks:

p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") negativeCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

More specifically, decreased expression levels of PP2A regulatory Bγ (or PPP2R2C) and B’ε (or PPP2R5E) subunit mRNAs in the hippocampus (Vogelsberg-Ragaglia et al.,2001), and cortical Bα subunit (Sontag et al.,2004b) have been reported in AD. PubMed:24653673

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.