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rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT)))

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Appears in Networks 1

TAU and Interaction Partners v1.2.5

TAU Interactions Section of NESTOR

In-Edges 3

act(complex(SCOMP:"PP2A Complex")) increases rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) View Subject | View Object

Thus, MTs inhibited the rate of tau dephosphorylation by ABaC. PubMed:10464280

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complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) View Subject | View Object

Here we show that heat shock protein 27 (Hsp27) preferentially binds pathological hyperphosphorylated tau and paired helical filaments tau directly but not non-phosphorylated tau. The formation of this complex altered the conformation of pathological hyperphosphorylated tau and reduced its concentration by facilitating its degradation and dephosphorylation. PubMed:14963027

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Annotations
Uberon
temporal cortex

p(HGNC:MAPT, pmod(Ph)) negativeCorrelation rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) View Subject | View Object

Thus, MTs inhibited the rate of tau dephosphorylation by ABaC. PubMed:10464280

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Out-Edges 4

rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) hasReactant p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

Appears in Networks:

rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

Thus, MTs inhibited the rate of tau dephosphorylation by ABaC. PubMed:10464280

Appears in Networks:

rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) hasProduct a(CHEBI:"phosphate(3-)") View Subject | View Object

Appears in Networks:

rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) hasProduct p(HGNC:MAPT) View Subject | View Object

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.