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temporal cortex

Name
temporal cortex
Namespace Keyword
Anatomy
Namespace
Uberon
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/anatomy/anatomy-20170511.belanno

Sample Annotated Edges 5

bp(GO:"neuron apoptotic process") negativeCorrelation p(HGNC:HSPB1) View Subject | View Object

Taken together, pathological hyperphosphorylated tau caused cell death, and Hsp27 attenuated the cell toxicity of pathological hyperphosphorylated tau. PubMed:14963027

Appears in Networks:
Annotations
Uberon
temporal cortex

complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases deg(p(HGNC:MAPT, pmod(Ph))) View Subject | View Object

Here we show that heat shock protein 27 (Hsp27) preferentially binds pathological hyperphosphorylated tau and paired helical filaments tau directly but not non-phosphorylated tau. The formation of this complex altered the conformation of pathological hyperphosphorylated tau and reduced its concentration by facilitating its degradation and dephosphorylation. PubMed:14963027

Appears in Networks:
Annotations
Uberon
temporal cortex

complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) View Subject | View Object

Here we show that heat shock protein 27 (Hsp27) preferentially binds pathological hyperphosphorylated tau and paired helical filaments tau directly but not non-phosphorylated tau. The formation of this complex altered the conformation of pathological hyperphosphorylated tau and reduced its concentration by facilitating its degradation and dephosphorylation. PubMed:14963027

Appears in Networks:
Annotations
Uberon
temporal cortex

p(HGNC:HSPB1) association p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

Here we show that heat shock protein 27 (Hsp27) preferentially binds pathological hyperphosphorylated tau and paired helical filaments tau directly but not non-phosphorylated tau. The formation of this complex altered the conformation of pathological hyperphosphorylated tau and reduced its concentration by facilitating its degradation and dephosphorylation. PubMed:14963027

Appears in Networks:
Annotations
Uberon
temporal cortex

p(HGNC:HSPB1) decreases act(p(HGNC:MAPT, pmod(Ph))) View Subject | View Object

Taken together, pathological hyperphosphorylated tau caused cell death, and Hsp27 attenuated the cell toxicity of pathological hyperphosphorylated tau. PubMed:14963027

Appears in Networks:
Annotations
Uberon
temporal cortex

Showing 5 of 11 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.