1. Catalog
  2. Nodes
  3. p(MESH:Neprilysin)

p(MESH:Neprilysin)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Neprilysin
Namespace
mesh
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/mesh-names.belns

Appears in Networks 1

Clearance systems in the brain-implications for Alzheimer disease. v1.0.1

In-Edges 1

path(MESH:"Alzheimer Disease") decreases p(MESH:Neprilysin) View Subject | View Object

First, expression of neprilysin is decreased in AD,126 especially in regions with high Aβ loads such as the hippocampus and temporal gyrus.127 PubMed:26195256

Appears in Networks:
Annotations
MeSH
Hippocampus
MeSH
Temporal Lobe

Out-Edges 1

p(MESH:Neprilysin) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) View Subject | View Object

Extracellular Aβ can also be degraded by proteases, such as neprily- sin (a membrane-anchored zinc metalloendopeptidase that degrades the Aβ monomers Aβ1-40 and Aβ1-42, and Aβ oligomers),119 matrix metalloproteinases 2, 3 and 9,120 glutamate carboxypeptidase II,121 endothelin-converting enzyme,122 tissue plasminogen activator,123 plasmin,120 angiotensin-converting enzyme,120 and insulin-degrading enzyme. PubMed:26195256

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.