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p(HGNC:SLC17A7)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
SLC17A7
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 3

MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations v1.0.0

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapse v1.0.0

In-Edges 8

p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:SLC17A7) View Subject | View Object

The percentages of VGLUT1-positive excitatory and GABA-positive inhibitory neurons were similar in neuronal cultures differentiated from control and patient iPSCs (Figures S2B and S2C) PubMed:27594586

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
MeSH
Frontotemporal Dementia

g(DBSNP:rs63751011) causesNoChange p(HGNC:SLC17A7) View Subject | View Object

The percentages of VGLUT1-positive excitatory and GABA-positive inhibitory neurons were similar in neuronal cultures differentiated from control and patient iPSCs (Figures S2B and S2C) PubMed:27594586

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
MeSH
Frontotemporal Dementia

a(PUBCHEM:9832404) causesNoChange p(HGNC:SLC17A7) View Subject | View Object

In females, hippocampal VGLUT1 was not affected by the Adnp genotype or NAP treatment (Supplemental Fig. S4A) PubMed:30664622

Appears in Networks:
Annotations
MeSH
Hippocampus
Gender
Female

a(PUBCHEM:9832404) causesNoChange p(HGNC:SLC17A7) View Subject | View Object

In the cerebral cortex, female Adnp+/− mice exhibited significantly reduced VGLUT1 expression, with no effect for NAP (Supplemental Fig. S4B). PubMed:30664622

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
Gender
Female

a(PUBCHEM:9832404) increases p(HGNC:SLC17A7) View Subject | View Object

When using area counting, NAP treatment was shown to provide full protection against VGLUT1 decreases in both the hippocampus and the cerebral cortex (Fig. 4f, h), whereas in terms of intensity changes in VGLUT1 expression, NAP effect was significant in the hippocampus (Fig. 4g), and exhibited a trend of improvement in the cortex (Fig. 4i). PubMed:30664622

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
MeSH
Hippocampus

p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange p(HGNC:SLC17A7) View Subject | View Object

In females, hippocampal VGLUT1 was not affected by the Adnp genotype or NAP treatment (Supplemental Fig. S4A) PubMed:30664622

Appears in Networks:
Annotations
MeSH
Hippocampus
Gender
Female

p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:SLC17A7) View Subject | View Object

In the cerebral cortex, female Adnp+/− mice exhibited significantly reduced VGLUT1 expression, with no effect for NAP (Supplemental Fig. S4B). PubMed:30664622

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
Gender
Female

p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:SLC17A7) View Subject | View Object

At the protein level, a significant reduction in VGLUT1 was observed in both the hippocampus (Fig. 4c–e, immunohistochemistry, 4FG, densitometry) and cerebral cortex (Fig. 4h, i, densitometry). PubMed:30664622

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
MeSH
Hippocampus

Out-Edges 3

p(HGNC:SLC17A7) hasVariant p(HGNC:SLC17A7, pmod(Ub)) View Subject | View Object

Appears in Networks:

p(HGNC:SLC17A7) regulates bp(GO:"glutamate homeostasis") View Subject | View Object

VGLUT1 is both necessary and sufficient for uptake and storage of glutamate, and thus comprises the sole determinant for an excitatory glutamatergic phenotype PubMed:30664622

Appears in Networks:

p(HGNC:SLC17A7) increases bp(GO:"L-glutamate import") View Subject | View Object

VGLUT1 is both necessary and sufficient for uptake and storage of glutamate, and thus comprises the sole determinant for an excitatory glutamatergic phenotype PubMed:30664622

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.