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a(CHEBI:"sodium chlorate")

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Entity

Name
sodium chlorate
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation v1.0.0

In-Edges 0

Out-Edges 2

a(CHEBI:"sodium chlorate") decreases complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) View Subject | View Object

Heparin blocks Tau binding by masking HSPG binding sites on Tau, and sodium chlorate inhibits HSPG sulfation. PubMed:25887395

Appears in Networks:

a(CHEBI:"sodium chlorate") decreases a(HBP:"Tau aggregates") View Subject | View Object

To test whether HSPGs also mediate BD Tau seeding, we titrated heparin and sodium chlorate, which inhibited seeding of all species (Fig. 8D). PubMed:25887395

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.