a(CHEBI:methamphetamine) increases path(MESH:Hallucinations)

View Subject View Object

PubMed:30061532

As detailed in the following paragraph, METH exerts disruptive effects on DA neurotransmission, which translate into abnormal stimulation of post-synaptic DA receptors, mainly D1-type DA receptors (D1R), thus leading to non-canonical signaling cascades sustaining behavioral alterations that overlap with schizophrenia-like symptoms (i.e., visual and auditory hallucinations and delusions)

Related Edges 9

• a(CHEBI:methamphetamine) decreases bp(GO:"dopamine secretion, neurotransmission")
• a(CHEBI:methamphetamine) decreases act(p(HGNCGENEFAMILY:"Dopamine receptors"))
• a(CHEBI:methamphetamine) decreases act(p(HGNC:DRD1))
• a(CHEBI:methamphetamine) increases bp(GO:"non-canonical Wnt signaling pathway")
• a(CHEBI:methamphetamine) increases path(MESH:Delusions)
• path(MESH:Delusions) association path(MESH:Schizophrenia)
• path(MESH:Hallucinations) association path(MESH:Schizophrenia)
• path(MESH:Schizophrenia) association path(MESH:Hallucinations)
• path(MESH:Schizophrenia) association path(MESH:Delusions)

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---