path(MESH:Hallucinations) association path(MESH:Schizophrenia)

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PubMed:30061532

As detailed in the following paragraph, METH exerts disruptive effects on DA neurotransmission, which translate into abnormal stimulation of post-synaptic DA receptors, mainly D1-type DA receptors (D1R), thus leading to non-canonical signaling cascades sustaining behavioral alterations that overlap with schizophrenia-like symptoms (i.e., visual and auditory hallucinations and delusions)

Related Edges 9

• a(CHEBI:methamphetamine) decreases bp(GO:"dopamine secretion, neurotransmission")
• a(CHEBI:methamphetamine) decreases act(p(HGNCGENEFAMILY:"Dopamine receptors"))
• a(CHEBI:methamphetamine) decreases act(p(HGNC:DRD1))
• a(CHEBI:methamphetamine) increases bp(GO:"non-canonical Wnt signaling pathway")
• a(CHEBI:methamphetamine) increases path(MESH:Hallucinations)
• a(CHEBI:methamphetamine) increases path(MESH:Delusions)
• path(MESH:Delusions) association path(MESH:Schizophrenia)
• path(MESH:Schizophrenia) association path(MESH:Hallucinations)
• path(MESH:Schizophrenia) association path(MESH:Delusions)

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