bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"apoptotic process")

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PubMed:27623715

Only middle-aged Tet-mev-1 mice showed JNK/MARK activation and Ca2+ overload, particularly in astrocytes with decreased hippocampal GFAP and S100ß, but without pathological features such as apoptosis, amyloidosis, and lactic acidosis in neurons and astrocytes. This led to decreasing levels of glial fibrillary acidic protein and S100β in the hippocampal area.

Related Edges 5

• bp(MESH:"Oxidative Stress") increases act(p(FPLX:JNK))
• bp(MESH:"Oxidative Stress") increases a(CHEBI:"calcium(2+)")
• bp(MESH:"Oxidative Stress") decreases p(HGNC:S100B)
• bp(MESH:"Oxidative Stress") causesNoChange path(MESH:"Acidosis, Lactic")
• bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"amyloid fibril formation")

Uberon

hippocampal formation

Cell Ontology (CL)

astrocyte

Cell Ontology (CL)

neuron

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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