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PubMed: 27623715

Title
Endogenous reactive oxygen species cause astrocyte defects and neuronal dysfunctions in the hippocampus: a new model for aging brain.
Journal
Aging cell
Volume
16
Issue
None
Pages
39-51
Date
2017-02-01
Authors
Hartman PS | Ishii N | Ishii T | Kawabe N | Miyazawa M | Nakata M | Onouchi H | Sugita K | Takanashi Y | Yamamoto Y | Yanagihara R | Yasuda K

Evidence eb62577b68
JSON

Only middle-aged Tet-mev-1 mice showed JNK/MARK activation and Ca2+ overload, particularly in astrocytes with decreased hippocampal GFAP and S100ß, but without pathological features such as apoptosis, amyloidosis, and lactic acidosis in neurons and astrocytes. This led to decreasing levels of glial fibrillary acidic protein and S100β in the hippocampal area.

bp(MESH:"Oxidative Stress") increases act(p(FPLX:JNK)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation
Cell Ontology (CL)
astrocyte

bp(MESH:"Oxidative Stress") increases a(CHEBI:"calcium(2+)") View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation
Cell Ontology (CL)
astrocyte

bp(MESH:"Oxidative Stress") decreases p(HGNC:S100B) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation
Cell Ontology (CL)
astrocyte

bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation
Cell Ontology (CL)
astrocyte
Cell Ontology (CL)
neuron

bp(MESH:"Oxidative Stress") causesNoChange path(MESH:"Acidosis, Lactic") View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation
Cell Ontology (CL)
astrocyte
Cell Ontology (CL)
neuron

bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"amyloid fibril formation") View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation
Cell Ontology (CL)
astrocyte
Cell Ontology (CL)
neuron

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.