bp(MESH:"Oxidative Stress") increases a(CHEBI:"calcium(2+)")

View Subject View Object

PubMed:27623715

Only middle-aged Tet-mev-1 mice showed JNK/MARK activation and Ca2+ overload, particularly in astrocytes with decreased hippocampal GFAP and S100ß, but without pathological features such as apoptosis, amyloidosis, and lactic acidosis in neurons and astrocytes. This led to decreasing levels of glial fibrillary acidic protein and S100β in the hippocampal area.

Related Edges 5

• bp(MESH:"Oxidative Stress") increases act(p(FPLX:JNK))
• bp(MESH:"Oxidative Stress") decreases p(HGNC:S100B)
• bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"apoptotic process")
• bp(MESH:"Oxidative Stress") causesNoChange path(MESH:"Acidosis, Lactic")
• bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"amyloid fibril formation")

Uberon

hippocampal formation

Cell Ontology (CL)

astrocyte

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---