Title

Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease.

Journal

The Journal of biological chemistry

Volume

284

Issue

None

Pages

20909-16

Date

2009-07-31

Authors

Ke YD | Ittner LM | Götz J

These include the scaffold protein JNK interacting protein (JIP) that is involved in the linkage of cargos to the kinesin-I motor complex via KLC (25, 28–33).This complex is formed by the kinesin heavy chain (KIF5; previously termed KHC), which interacts with microtubules, and kinesin light chain (KLC), which mediates cargo linkage. In addition, scaffolding proteins are involved such as the JIP1 that binds to KLC (21).

Thus, the lack of kinesin/JIP1 interaction occurs together with an aberrant Tau/JIP1 interaction in K3 brains.Taken together, our data reveal that hyperphosphorylated Tau competes with KLC for the interaction with JIP1.

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