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PubMed: 27260836

Title
Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease.
Journal
Neurobiology of disease
Volume
94
Issue
None
Pages
32-43
Date
2016-10-01
Authors
Ando K | Authelet M | Belkouch M | Brion JP | Duyckaerts C | Ndjim M | Potier MC | Sazdovitch V | Suain V | Tomimura K | Vergara C | Yilmaz Z

Evidence 0c8f0d46ce
JSON

Phosphatidylinositol binding clathrin assembly protein, PICALM (aka CALM) assembles adaptor protein-2 (AP-2) to clathrin, thus participating in clathrin-mediated endocytosis. We have previously reported that the level of full-length PICALM is decreased in AD brains; PICALM was co-localised with phosphorylated tau in NFTs and in granulovacuolar degenerations (GVDs) in the brains of AD patients and of individuals with Down syndrome but was not observed in amyloid plaques (Ando et al., 2013).

bp(GO:"clathrin-dependent endocytosis") positiveCorrelation complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) View Subject | View Object

Appears in Networks:

complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) positiveCorrelation bp(GO:"clathrin-dependent endocytosis") View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ph)) association p(HGNC:PICALM) View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease
Disease Ontology (DO)
Down syndrome

p(HGNC:PICALM) increases complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) View Subject | View Object

Appears in Networks:

p(HGNC:PICALM) negativeCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease
Disease Ontology (DO)
Down syndrome

p(HGNC:PICALM) association p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease
Disease Ontology (DO)
Down syndrome

path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PICALM) View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease
Disease Ontology (DO)
Down syndrome

Evidence 4f2699edfb
JSON

Double immunostaining for PICALM and anti-phosphotau antibodies (AT8 and PHF1) showed a co-localisation of PICALM and phosphotau in Pick bodies of Pick disease

complex(GO:"Pick body") positiveCorrelation path(MESH:"Pick Disease of the Brain") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Pick's disease

path(MESH:"Pick Disease of the Brain") positiveCorrelation complex(GO:"Pick body") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Pick's disease

Evidence d386e59125
JSON

A highly significant correlation was found between decreased levels of PICALM and increased levels of LC3-II (p=0.0032) or decreased levels of Beclin-1 (p=0.0295) in the total brain lysates from these diseases (Fig 6D,E).

p(HGNC:BECN1) positiveCorrelation p(HGNC:PICALM) View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease
Disease Ontology (DO)
Down syndrome
Disease Ontology (DO)
Pick's disease
Disease Ontology (DO)
progressive supranuclear palsy

p(HGNC:MAP1LC3B) negativeCorrelation p(HGNC:PICALM) View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease
Disease Ontology (DO)
Down syndrome
Disease Ontology (DO)
Pick's disease
Disease Ontology (DO)
progressive supranuclear palsy

p(HGNC:PICALM) negativeCorrelation p(HGNC:MAP1LC3B) View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease
Disease Ontology (DO)
Down syndrome
Disease Ontology (DO)
Pick's disease
Disease Ontology (DO)
progressive supranuclear palsy

p(HGNC:PICALM) positiveCorrelation p(HGNC:BECN1) View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease
Disease Ontology (DO)
Down syndrome
Disease Ontology (DO)
Pick's disease
Disease Ontology (DO)
progressive supranuclear palsy

Evidence 04b0d8fecc
JSON

In PSP cases, both coiled bodies (Fig. 2 D-F) and NFTs (Fig. 2G-I) in the striatum showed a complete co-localisation of PICALM and phosphotau immunoreactivies.

p(HGNC:MAPT, pmod(Ph)) association p(HGNC:PICALM) View Subject | View Object

Appears in Networks:
Annotations
Uberon
striatum
Disease Ontology (DO)
progressive supranuclear palsy

p(HGNC:PICALM) association p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
striatum
Disease Ontology (DO)
progressive supranuclear palsy

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