Title

Nicotinic α4β2 acetylcholine receptors and cognitive function in Parkinson's disease.

Journal

Acta neurologica Scandinavica

Volume

130

Issue

None

Pages

164-71

Date

2014-09-01

Authors

Schiller M | Samnick S | Buck A | Spiegel J | Dillmann U | Faßbender K | Lorenz R | Ong MF

The most intense accumulation of 5-I-A-85380 was detected in both thalami, pons and midbrain, and both nuclei lentiformes

We found high correlation coefficients for four brain regions (right superior parietal lobule, left thalamus, right pos- terior subcortical region, and left posterior subcor- tical region) and two CERAD subtests (Word List Intrusions and Boston Naming Test), some of them were statistically significant.

The right cerebellar white matter revealed a sig- nificantly higher 5-I-A-85380 uptake than the left cerebellar white matter.

Furthermore, we studied in these 17 IPD patients (at Hoehn and Yahr stage 1 and 2) whether there were differences of the a4b2 nAchR densities in the brain hemisphere contralateral to the clinically more affected body side (=contralat- eral hemisphere) compared to the brain hemi- sphere ipsilateral to the clinically more affected body side (=ipsilateral hemisphere).

Performance was impaired, compared with a normal population, in the subtests Figure Recall and Figure Saving. These both subtests examined non-verbal functions, namely non-verbal memory and visuoconstructive ability.

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