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a(HBP:"dystrophic neurite")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
dystrophic neurite
Namespace
HBP
Namespace Version
20181119
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/90e1cb9e5e882703380c9db8d4915ac6f3cba137/export/hbp-names.belns

Appears in Networks 3

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Alzheimer’s disease and the autophagic-lysosomal system v1.0.0

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

In-Edges 9

p(HBP:"cis p-tau") partOf a(HBP:"dystrophic neurite") View Subject | View Object

Appears in Networks:

p(HGNC:ITPKB) partOf a(HBP:"dystrophic neurite") View Subject | View Object

Appears in Networks:

p(MGI:Syk, pmod(Ph)) partOf a(HBP:"dystrophic neurite") View Subject | View Object

Appears in Networks:

path(MESH:"Plaque, Amyloid") partOf a(HBP:"dystrophic neurite") View Subject | View Object

Appears in Networks:

complex(a(GO:autophagosome), a(HBP:"dystrophic neurite")) hasComponent a(HBP:"dystrophic neurite") View Subject | View Object

Appears in Networks:

a(GO:autophagosome) association a(HBP:"dystrophic neurite") View Subject | View Object

AV accumulations are not specific to the degenerative phenomena of AD; however, in AD brain, the extensive numbers of dystrophic neurites (Masliah et al. 1993; Schmidt et al. 1994), their characteristic marked distension, and the fact that they are predominantly filled with AVs distinguish the pattern and magnitude of this pathology from that of other aging-related neurodegenerative diseases (Benzing et al. 1993). PubMed:22908190

Appears in Networks:

a(HBP:"paired helical filaments") association a(HBP:"dystrophic neurite") View Subject | View Object

Polyclonal antibodies to the classical paired helical filaments (PHFs) found in the neurofibrillary tangles and dystrophic neurites of AD were first raised in about 1982, allowing exploration of the component(s) of PHFs using immunochemical approaches (Ihara et al. 1983) PubMed:22908190

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(MESH:Ubiquitin) association a(HBP:"dystrophic neurite") View Subject | View Object

In AD cortical sections, we observed that NFTs and dystrophic neurites (Fig. 1) and, unexpectedly, granulovacuolar changes (Fig. 1, inset) were intensely immunolabeled by the DF2 monoclonal. When mild fixation conditions were used, innumerable neuropil threads were also detected. PubMed:22908190

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"dystrophic neurite") View Subject | View Object

AV accumulations are not specific to the degenerative phenomena of AD; however, in AD brain, the extensive numbers of dystrophic neurites (Masliah et al. 1993; Schmidt et al. 1994), their characteristic marked distension, and the fact that they are predominantly filled with AVs distinguish the pattern and magnitude of this pathology from that of other aging-related neurodegenerative diseases (Benzing et al. 1993). PubMed:22908190

Appears in Networks:

Out-Edges 4

a(HBP:"dystrophic neurite") association a(HBP:"paired helical filaments") View Subject | View Object

Polyclonal antibodies to the classical paired helical filaments (PHFs) found in the neurofibrillary tangles and dystrophic neurites of AD were first raised in about 1982, allowing exploration of the component(s) of PHFs using immunochemical approaches (Ihara et al. 1983) PubMed:22908190

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(HBP:"dystrophic neurite") association a(MESH:Ubiquitin) View Subject | View Object

In AD cortical sections, we observed that NFTs and dystrophic neurites (Fig. 1) and, unexpectedly, granulovacuolar changes (Fig. 1, inset) were intensely immunolabeled by the DF2 monoclonal. When mild fixation conditions were used, innumerable neuropil threads were also detected. PubMed:22908190

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
MeSH
Alzheimer Disease

a(HBP:"dystrophic neurite") association a(GO:autophagosome) View Subject | View Object

AV accumulations are not specific to the degenerative phenomena of AD; however, in AD brain, the extensive numbers of dystrophic neurites (Masliah et al. 1993; Schmidt et al. 1994), their characteristic marked distension, and the fact that they are predominantly filled with AVs distinguish the pattern and magnitude of this pathology from that of other aging-related neurodegenerative diseases (Benzing et al. 1993). PubMed:22908190

Appears in Networks:

a(HBP:"dystrophic neurite") positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

AV accumulations are not specific to the degenerative phenomena of AD; however, in AD brain, the extensive numbers of dystrophic neurites (Masliah et al. 1993; Schmidt et al. 1994), their characteristic marked distension, and the fact that they are predominantly filled with AVs distinguish the pattern and magnitude of this pathology from that of other aging-related neurodegenerative diseases (Benzing et al. 1993). PubMed:22908190

Appears in Networks:

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.