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p(HGNC:CHRNG) increases a(MESH:"Receptors, Nicotinic") View Subject | View Object

Nicotinic receptors are formed by five different subunits: α, β, δ, and γ (fetal) or ε (adult) PubMed:26813123

act(p(HGNC:CHRNG)) increases bp(GO:"long-term synaptic potentiation") View Subject | View Object

In receptors harboring the gamma subunit, agonist-induced receptor activation results in a long-lasting open channel time. The large agonist-induced current in turn leads to local intermittent depolarization and adjustments to protein-protein interactions that favor receptor clustering. As the depolarization increases, transcription of the epsilon subunit is increased dramatically (183). PubMed:19126755

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.