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complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG))

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Components

Appears in Networks 1

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

In-Edges 1

composite(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG)) View Subject | View Object

Green and colleagues (191, 365, 485) report that nAChR assembly proceeds in the endoplasmic reticulum where specific subunits are added sequentially to the receptor complex according to the conformations the complex assumes. In this model, nAChR subunits are synthesized, and initial polypeptide folding favors the rapid recognition and interaction between alpha-beta-gamma subunits to produce trimers that in turn form a structure favorable to the addition of the delta subunit and finally the second alpha subunit. PubMed:19126755

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Out-Edges 4

complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG)) hasComponent p(HGNC:CHRNA1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG)) hasComponent p(HGNC:CHRNB1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG)) hasComponent p(HGNC:CHRNG) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) View Subject | View Object

Green and colleagues (191, 365, 485) report that nAChR assembly proceeds in the endoplasmic reticulum where specific subunits are added sequentially to the receptor complex according to the conformations the complex assumes. In this model, nAChR subunits are synthesized, and initial polypeptide folding favors the rapid recognition and interaction between alpha-beta-gamma subunits to produce trimers that in turn form a structure favorable to the addition of the delta subunit and finally the second alpha subunit. PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.